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Discovery and Optimization of a Compound Series Active against Trypanosoma cruzi, the Causative Agent of Chagas Disease.
Harrison JR, Sarkar S, Hampton S, Riley J, Stojanovski L, Sahlberg C, Appelqvist P, Erath J, Mathan V, Rodriguez A, Kaiser M, Pacanowska DG, Read KD, Johansson NG, Gilbert IH. Harrison JR, et al. Among authors: rodriguez a. J Med Chem. 2020 Mar 26;63(6):3066-3089. doi: 10.1021/acs.jmedchem.9b01852. Epub 2020 Mar 5. J Med Chem. 2020. PMID: 32134269
Identification of small-molecule inhibitors of Trypansoma cruzi replication.
Germain AR, Carmody LC, Dockendorff C, Galan-Rodriguez C, Rodriguez A, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Schreiber SL, Munoz B. Germain AR, et al. Among authors: rodriguez a. Bioorg Med Chem Lett. 2011 Dec 1;21(23):7197-200. doi: 10.1016/j.bmcl.2011.09.057. Epub 2011 Sep 29. Bioorg Med Chem Lett. 2011. PMID: 22018462
Antitrypanosomal lead discovery: identification of a ligand-efficient inhibitor of Trypanosoma cruzi CYP51 and parasite growth.
Andriani G, Amata E, Beatty J, Clements Z, Coffey BJ, Courtemanche G, Devine W, Erath J, Juda CE, Wawrzak Z, Wood JT, Lepesheva GI, Rodriguez A, Pollastri MP. Andriani G, et al. Among authors: rodriguez a. J Med Chem. 2013 Mar 28;56(6):2556-67. doi: 10.1021/jm400012e. Epub 2013 Mar 13. J Med Chem. 2013. PMID: 23448316 Free PMC article.
Diversity-oriented synthesis yields a new drug lead for treatment of chagas disease.
Dandapani S, Germain AR, Jewett I, le Quement S, Marie JC, Muncipinto G, Duvall JR, Carmody LC, Perez JR, Engel JC, Gut J, Kellar D, Siqueira-Neto JL, McKerrow JH, Kaiser M, Rodriguez A, Palmer MA, Foley M, Schreiber SL, Munoz B. Dandapani S, et al. Among authors: rodriguez a. ACS Med Chem Lett. 2013 Dec 29;5(2):149-53. doi: 10.1021/ml400403u. eCollection 2014 Feb 13. ACS Med Chem Lett. 2013. PMID: 24900788 Free PMC article.
High throughput screening for anti-Trypanosoma cruzi drug discovery.
Alonso-Padilla J, Rodríguez A. Alonso-Padilla J, et al. Among authors: rodriguez a. PLoS Negl Trop Dis. 2014 Dec 4;8(12):e3259. doi: 10.1371/journal.pntd.0003259. eCollection 2014 Dec. PLoS Negl Trop Dis. 2014. PMID: 25474364 Free PMC article. Review.
8,216 results