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Role of Proinsulin Self-Association in Mutant INS Gene-Induced Diabetes of Youth.
Sun J, Xiong Y, Li X, Haataja L, Chen W, Mir SA, Lv L, Madley R, Larkin D, Anjum A, Dhayalan B, Rege N, Wickramasinghe NP, Weiss MA, Itkin-Ansari P, Kaufman RJ, Ostrov DA, Arvan P, Liu M. Sun J, et al. Among authors: wickramasinghe np. Diabetes. 2020 May;69(5):954-964. doi: 10.2337/db19-1106. Epub 2020 Mar 5. Diabetes. 2020. PMID: 32139596 Free PMC article.
Evolution of insulin at the edge of foldability and its medical implications.
Rege NK, Liu M, Yang Y, Dhayalan B, Wickramasinghe NP, Chen YS, Rahimi L, Guo H, Haataja L, Sun J, Ismail-Beigi F, Phillips NB, Arvan P, Weiss MA. Rege NK, et al. Among authors: wickramasinghe np. Proc Natl Acad Sci U S A. 2020 Nov 24;117(47):29618-29628. doi: 10.1073/pnas.2010908117. Epub 2020 Nov 5. Proc Natl Acad Sci U S A. 2020. PMID: 33154160 Free PMC article.
An ultra-stable single-chain insulin analog resists thermal inactivation and exhibits biological signaling duration equivalent to the native protein.
Glidden MD, Aldabbagh K, Phillips NB, Carr K, Chen YS, Whittaker J, Phillips M, Wickramasinghe NP, Rege N, Swain M, Peng Y, Yang Y, Lawrence MC, Yee VC, Ismail-Beigi F, Weiss MA. Glidden MD, et al. Among authors: wickramasinghe np. J Biol Chem. 2018 Jan 5;293(1):47-68. doi: 10.1074/jbc.M117.808626. Epub 2017 Nov 7. J Biol Chem. 2018. PMID: 29114035 Free PMC article.
22 results