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Synthesis of 11,12-dihydro benzo[c]phenanthridines via a Pd-catalyzed unusual construction of isocoumarin ring/FeCl3-mediated intramolecular arene-allyl cyclization: First identification of a benzo[c]phenanthridine based PDE4 inhibitor.
Thirupataiah B, Reddy GS, Ghule SS, Kumar JS, Mounika G, Hossain KA, Mudgal J, Mathew JE, Shenoy GG, Parsa KVL, Pal M. Thirupataiah B, et al. Among authors: mathew je. Bioorg Chem. 2020 Apr;97:103691. doi: 10.1016/j.bioorg.2020.103691. Epub 2020 Feb 25. Bioorg Chem. 2020. PMID: 32143019
InCl3 mediated heteroarylation of indoles and their derivatization via CH activation strategy: Discovery of 2-(1H-indol-3-yl)-quinoxaline derivatives as a new class of PDE4B selective inhibitors for arthritis and/or multiple sclerosis.
Sunke R, Bankala R, Thirupataiah B, Ramarao EVVS, Kumar JS, Doss HM, Medishetti R, Kulkarni P, Kapavarapu RK, Rasool M, Mudgal J, Mathew JE, Shenoy GG, Parsa KVL, Pal M. Sunke R, et al. Among authors: mathew je. Eur J Med Chem. 2019 Jul 15;174:198-215. doi: 10.1016/j.ejmech.2019.04.020. Epub 2019 Apr 16. Eur J Med Chem. 2019. PMID: 31035240
PdCl2-catalyzed synthesis of a new class of isocoumarin derivatives containing aminosulfonyl / aminocarboxamide moiety: First identification of a isocoumarin based PDE4 inhibitor.
Thirupataiah B, Mounika G, Reddy GS, Kumar JS, Hossain KA, Medishetti R, Samarpita S, Rasool M, Mudgal J, Mathew JE, Shenoy GG, Rao CM, Chatti K, Parsa KVL, Pal M. Thirupataiah B, et al. Among authors: mathew je. Eur J Med Chem. 2021 Oct 5;221:113514. doi: 10.1016/j.ejmech.2021.113514. Epub 2021 May 6. Eur J Med Chem. 2021. PMID: 33992926
CuCl2-catalyzed inexpensive, faster and ligand/additive free synthesis of isoquinolin-1(2H)-one derivatives via the coupling-cyclization strategy: Evaluation of a new class of compounds as potential PDE4 inhibitors.
Thirupataiah B, Mounika G, Sujeevan Reddy G, Sandeep Kumar J, Kapavarapu R, Medishetti R, Mudgal J, Mathew JE, Shenoy GG, Mallikarjuna Rao C, Chatti K, V L Parsa K, Pal M. Thirupataiah B, et al. Among authors: mathew je. Bioorg Chem. 2021 Oct;115:105265. doi: 10.1016/j.bioorg.2021.105265. Epub 2021 Aug 13. Bioorg Chem. 2021. PMID: 34426160
40 results