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PD-L1 engagement on T cells promotes self-tolerance and suppression of neighboring macrophages and effector T cells in cancer.
Diskin B, Adam S, Cassini MF, Sanchez G, Liria M, Aykut B, Buttar C, Li E, Sundberg B, Salas RD, Chen R, Wang J, Kim M, Farooq MS, Nguy S, Fedele C, Tang KH, Chen T, Wang W, Hundeyin M, Rossi JAK, Kurz E, Haq MIU, Karlen J, Kruger E, Sekendiz Z, Wu D, Shadaloey SAA, Baptiste G, Werba G, Selvaraj S, Loomis C, Wong KK, Leinwand J, Miller G. Diskin B, et al. Among authors: wu d. Nat Immunol. 2020 Apr;21(4):442-454. doi: 10.1038/s41590-020-0620-x. Epub 2020 Mar 9. Nat Immunol. 2020. PMID: 32152508
Targeting Piezo1 unleashes innate immunity against cancer and infectious disease.
Aykut B, Chen R, Kim JI, Wu D, Shadaloey SAA, Abengozar R, Preiss P, Saxena A, Pushalkar S, Leinwand J, Diskin B, Wang W, Werba G, Berman M, Lee SKB, Khodadadi-Jamayran A, Saxena D, Coetzee WA, Miller G. Aykut B, et al. Among authors: wu d. Sci Immunol. 2020 Aug 21;5(50):eabb5168. doi: 10.1126/sciimmunol.abb5168. Sci Immunol. 2020. PMID: 32826342
The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL.
Aykut B, Pushalkar S, Chen R, Li Q, Abengozar R, Kim JI, Shadaloey SA, Wu D, Preiss P, Verma N, Guo Y, Saxena A, Vardhan M, Diskin B, Wang W, Leinwand J, Kurz E, Kochen Rossi JA, Hundeyin M, Zambrinis C, Li X, Saxena D, Miller G. Aykut B, et al. Among authors: wu d. Nature. 2019 Oct;574(7777):264-267. doi: 10.1038/s41586-019-1608-2. Epub 2019 Oct 2. Nature. 2019. PMID: 31578522 Free PMC article.
Identification of a RIP1 Kinase Inhibitor Clinical Candidate (GSK3145095) for the Treatment of Pancreatic Cancer.
Harris PA, Marinis JM, Lich JD, Berger SB, Chirala A, Cox JA, Eidam PM, Finger JN, Gough PJ, Jeong JU, Kang J, Kasparcova V, Leister LK, Mahajan MK, Miller G, Nagilla R, Ouellette MT, Reilly MA, Rendina AR, Rivera EJ, Sun HH, Thorpe JH, Totoritis RD, Wang W, Wu D, Zhang D, Bertin J, Marquis RW. Harris PA, et al. Among authors: wu d. ACS Med Chem Lett. 2019 May 9;10(6):857-862. doi: 10.1021/acsmedchemlett.9b00108. eCollection 2019 Jun 13. ACS Med Chem Lett. 2019. PMID: 31223438 Free PMC article.
Machine learning-optimized targeted detection of alternative splicing.
Yang K, Islas N, Jewell S, Wu D, Jha A, Radens CM, Pleiss JA, Lynch KW, Barash Y, Choi PS. Yang K, et al. Among authors: wu d. Nucleic Acids Res. 2024 Dec 27:gkae1260. doi: 10.1093/nar/gkae1260. Online ahead of print. Nucleic Acids Res. 2024. PMID: 39727154
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