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Tumor cell-intrinsic PD-1 receptor is a tumor suppressor and mediates resistance to PD-1 blockade therapy.
Wang X, Yang X, Zhang C, Wang Y, Cheng T, Duan L, Tong Z, Tan S, Zhang H, Saw PE, Gu Y, Wang J, Zhang Y, Shang L, Liu Y, Jiang S, Yan B, Li R, Yang Y, Yu J, Chen Y, Gao GF, Ye Q, Gao S. Wang X, et al. Among authors: wang j, wang y. Proc Natl Acad Sci U S A. 2020 Mar 24;117(12):6640-6650. doi: 10.1073/pnas.1921445117. Epub 2020 Mar 11. Proc Natl Acad Sci U S A. 2020. PMID: 32161124 Free PMC article.
A small molecule protects mitochondrial integrity by inhibiting mTOR activity.
Cao R, Li L, Ying Z, Cao Z, Ma Y, Mao X, Li J, Qi X, Zhang Z, Wang X. Cao R, et al. Among authors: wang x. Proc Natl Acad Sci U S A. 2019 Nov 12;116(46):23332-23338. doi: 10.1073/pnas.1911246116. Epub 2019 Oct 25. Proc Natl Acad Sci U S A. 2019. PMID: 31653761 Free PMC article.
DMDRMR-Mediated Regulation of m6A-Modified CDK4 by m6A Reader IGF2BP3 Drives ccRCC Progression.
Gu Y, Niu S, Wang Y, Duan L, Pan Y, Tong Z, Zhang X, Yang Z, Peng B, Wang X, Han X, Li Y, Cheng T, Liu Y, Shang L, Liu T, Yang X, Sun M, Jiang S, Zhang C, Zhang N, Ye Q, Gao S. Gu Y, et al. Among authors: wang x, wang y. Cancer Res. 2021 Feb 15;81(4):923-934. doi: 10.1158/0008-5472.CAN-20-1619. Epub 2020 Dec 8. Cancer Res. 2021. PMID: 33293428
LCDR regulates the integrity of lysosomal membrane by hnRNP K-stabilized LAPTM5 transcript and promotes cell survival.
Yang X, Wen Y, Liu S, Duan L, Liu T, Tong Z, Wang Z, Gu Y, Xi Y, Wang X, Luo D, Zhang R, Liu Y, Wang Y, Cheng T, Jiang S, Zhu X, Yang X, Pan Y, Cheng S, Ye Q, Chen J, Xu X, Gao S. Yang X, et al. Among authors: wang x, wang z, wang y. Proc Natl Acad Sci U S A. 2022 Feb 1;119(5):e2110428119. doi: 10.1073/pnas.2110428119. Proc Natl Acad Sci U S A. 2022. PMID: 35091468 Free PMC article.
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