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Serine/threonine phosphatase PP2A is essential for optimal B cell function.
Meidan E, Li H, Pan W, Kono M, Yu S, Kyttaris VC, Ioannidis C, Rodriguez Rodriguez N, Crispin JC, Apostolidis SA, Lee P, Manis J, Sharabi A, Tsokos MG, Tsokos GC. Meidan E, et al. Among authors: rodriguez rodriguez n. JCI Insight. 2020 Mar 12;5(5):e130655. doi: 10.1172/jci.insight.130655. JCI Insight. 2020. PMID: 32161189 Free PMC article.
cAMP responsive element modulator (CREM) α mediates chromatin remodeling of CD8 during the generation of CD3+ CD4- CD8- T cells.
Hedrich CM, Crispín JC, Rauen T, Ioannidis C, Koga T, Rodriguez Rodriguez N, Apostolidis SA, Kyttaris VC, Tsokos GC. Hedrich CM, et al. Among authors: rodriguez rodriguez n. J Biol Chem. 2014 Jan 24;289(4):2361-70. doi: 10.1074/jbc.M113.523605. Epub 2013 Dec 2. J Biol Chem. 2014. PMID: 24297179 Free PMC article. Clinical Trial.
Phosphatase PP2A is requisite for the function of regulatory T cells.
Apostolidis SA, Rodríguez-Rodríguez N, Suárez-Fueyo A, Dioufa N, Ozcan E, Crispín JC, Tsokos MG, Tsokos GC. Apostolidis SA, et al. Among authors: rodriguez rodriguez n. Nat Immunol. 2016 May;17(5):556-64. doi: 10.1038/ni.3390. Epub 2016 Mar 14. Nat Immunol. 2016. PMID: 26974206 Free PMC article.
PPP2R2B hypermethylation causes acquired apoptosis deficiency in systemic autoimmune diseases.
Madera-Salcedo IK, Sánchez-Hernández BE, Svyryd Y, Esquivel-Velázquez M, Rodríguez-Rodríguez N, Trejo-Zambrano MI, García-González HB, Hernández-Molina G, Mutchinick OM, Alcocer-Varela J, Rosetti F, Crispín JC. Madera-Salcedo IK, et al. Among authors: rodriguez rodriguez n. JCI Insight. 2019 Jul 23;5(16):e126457. doi: 10.1172/jci.insight.126457. JCI Insight. 2019. PMID: 31335320 Free PMC article.
TCR-α/β CD4- CD8- double negative T cells arise from CD8+ T cells.
Rodríguez-Rodríguez N, Flores-Mendoza G, Apostolidis SA, Rosetti F, Tsokos GC, Crispín JC. Rodríguez-Rodríguez N, et al. J Leukoc Biol. 2020 Sep;108(3):851-857. doi: 10.1002/JLB.1AB0120-548R. Epub 2020 Feb 13. J Leukoc Biol. 2020. PMID: 32052478 Free PMC article.
Protein phosphatase 2A B55β limits CD8+ T cell lifespan following cytokine withdrawal.
Rodríguez-Rodríguez N, Madera-Salcedo IK, Cisneros-Segura JA, García-González HB, Apostolidis SA, Saint-Martin A, Esquivel-Velázquez M, Nguyen T, Romero-Rodríguez DP, Tsokos GC, Alcocer-Varela J, Rosetti F, Crispín JC. Rodríguez-Rodríguez N, et al. J Clin Invest. 2020 Nov 2;130(11):5989-6004. doi: 10.1172/JCI129479. J Clin Invest. 2020. PMID: 32750040 Free PMC article.
45 results