Choi I - Search Results

1

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration.

Choi I, Zhang Y, Seegobin SP, Pruvost M, Wang Q, Purtell K, Zhang B, Yue Z. Choi I, et al. Nat Commun. 2020 Mar 13;11(1):1386. doi: 10.1038/s41467-020-15119-w. Nat Commun. 2020. PMID: 32170061 Free PMC article.

2

The landscape of multiscale transcriptomic networks and key regulators in Parkinson's disease.

Wang Q, Zhang Y, Wang M, Song WM, Shen Q, McKenzie A, Choi I, Zhou X, Pan PY, Yue Z, Zhang B. Wang Q, et al. Among authors: choi i. Nat Commun. 2019 Nov 20;10(1):5234. doi: 10.1038/s41467-019-13144-y. Nat Commun. 2019. PMID: 31748532 Free PMC article.

3

Autophagy protein NRBF2 has reduced expression in Alzheimer's brains and modulates memory and amyloid-beta homeostasis in mice.

Lachance V, Wang Q, Sweet E, Choi I, Cai CZ, Zhuang XX, Zhang Y, Jiang JL, Blitzer RD, Bozdagi-Gunal O, Zhang B, Lu JH, Yue Z. Lachance V, et al. Among authors: choi i. Mol Neurodegener. 2019 Nov 27;14(1):43. doi: 10.1186/s13024-019-0342-4. Mol Neurodegener. 2019. PMID: 31775806 Free PMC article.

4

Synj1 haploinsufficiency causes dopamine neuron vulnerability and alpha-synuclein accumulation in mice.

Pan PY, Sheehan P, Wang Q, Zhu X, Zhang Y, Choi I, Li X, Saenz J, Zhu J, Wang J, El Gaamouch F, Zhu L, Cai D, Yue Z. Pan PY, et al. Among authors: choi i. Hum Mol Genet. 2020 Aug 11;29(14):2300-2312. doi: 10.1093/hmg/ddaa080. Hum Mol Genet. 2020. PMID: 32356558 Free PMC article.

5

Synucleinphagy: a microglial "community cleanup program" for neuroprotection.

Choi I, Seegobin SP, Liang D, Yue Z. Choi I, et al. Autophagy. 2020 Sep;16(9):1718-1720. doi: 10.1080/15548627.2020.1774149. Epub 2020 Jun 9. Autophagy. 2020. PMID: 32453651 Free PMC article.

6

Progress in LRRK2-Associated Parkinson's Disease Animal Models.

Seegobin SP, Heaton GR, Liang D, Choi I, Blanca Ramirez M, Tang B, Yue Z. Seegobin SP, et al. Among authors: choi i. Front Neurosci. 2020 Jul 15;14:674. doi: 10.3389/fnins.2020.00674. eCollection 2020. Front Neurosci. 2020. PMID: 32765209 Free PMC article. Review.

7

Selective autophagy of AKAP11 activates cAMP/PKA to fuel mitochondrial metabolism and tumor cell growth.

Deng Z, Li X, Blanca Ramirez M, Purtell K, Choi I, Lu JH, Yu Q, Yue Z. Deng Z, et al. Among authors: choi i. Proc Natl Acad Sci U S A. 2021 Apr 6;118(14):e2020215118. doi: 10.1073/pnas.2020215118. Proc Natl Acad Sci U S A. 2021. PMID: 33785595 Free PMC article.

8

Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy.

Choi I, Heaton GR, Lee YK, Yue Z. Choi I, et al. Sci Adv. 2022 Oct 28;8(43):eabn1298. doi: 10.1126/sciadv.abn1298. Epub 2022 Oct 26. Sci Adv. 2022. PMID: 36288297 Free PMC article. Review.

9

Autophagy enables microglia to engage amyloid plaques and prevents microglial senescence.

Choi I, Wang M, Yoo S, Xu P, Seegobin SP, Li X, Han X, Wang Q, Peng J, Zhang B, Yue Z. Choi I, et al. Nat Cell Biol. 2023 Jul;25(7):963-974. doi: 10.1038/s41556-023-01158-0. Epub 2023 May 25. Nat Cell Biol. 2023. PMID: 37231161 Free PMC article.

10

Molecular profiling of human substantia nigra identifies diverse neuron types associated with vulnerability in Parkinson's disease.

Wang Q, Wang M, Choi I, Sarrafha L, Liang M, Ho L, Farrell K, Beaumont KG, Sebra R, De Sanctis C, Crary JF, Ahfeldt T, Blanchard J, Neavin D, Powell J, Davis DA, Sun X, Zhang B, Yue Z. Wang Q, et al. Among authors: choi i. Sci Adv. 2024 Jan 12;10(2):eadi8287. doi: 10.1126/sciadv.adi8287. Epub 2024 Jan 10. Sci Adv. 2024. PMID: 38198537 Free PMC article.

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