Pang Y - Search Results

1

Significant combination of Aβ aggregation inhibitory and neuroprotective properties in silico, in vitro and in vivo by bis(propyl)-cognitin, a multifunctional anti-Alzheimer's agent.

Hu S, Xian Y, Fan Y, Mak S, Wang J, Tang J, Pang Y, Pi R, Tsim KW, Liu F, Lin Z, Han Y. Hu S, et al. Among authors: pang y. Eur J Pharmacol. 2020 Jun 5;876:173065. doi: 10.1016/j.ejphar.2020.173065. Epub 2020 Mar 20. Eur J Pharmacol. 2020. PMID: 32171792

2

Promising multifunctional anti-Alzheimer's dimer bis(7)-Cognitin acting as an activator of protein kinase C regulates activities of alpha-secretase and BACE-1 concurrently.

Fu H, Dou J, Li W, Cui W, Mak S, Hu Q, Luo J, Lam CS, Pang Y, Youdim MB, Han Y. Fu H, et al. Among authors: pang y. Eur J Pharmacol. 2009 Nov 25;623(1-3):14-21. doi: 10.1016/j.ejphar.2009.09.013. Epub 2009 Sep 16. Eur J Pharmacol. 2009. PMID: 19765582

3

Bis(propyl)-cognitin protects against glutamate-induced neuro-excitotoxicity via concurrent regulation of NO, MAPK/ERK and PI3-K/Akt/GSK3β pathways.

Hu S, Cui W, Mak S, Tang J, Choi C, Pang Y, Han Y. Hu S, et al. Among authors: pang y. Neurochem Int. 2013 Mar;62(4):468-77. doi: 10.1016/j.neuint.2013.01.022. Epub 2013 Jan 26. Neurochem Int. 2013. PMID: 23357479

4

Substantial Neuroprotective and Neurite Outgrowth-Promoting Activities by Bis(propyl)-cognitin via the Activation of Alpha7-nAChR, a Promising Anti-Alzheimer's Dimer.

Hu S, Cui W, Mak S, Xu D, Hu Y, Tang J, Choi C, Lee M, Pang Y, Han Y. Hu S, et al. Among authors: pang y. ACS Chem Neurosci. 2015 Sep 16;6(9):1536-45. doi: 10.1021/acschemneuro.5b00108. Epub 2015 Jul 16. ACS Chem Neurosci. 2015. PMID: 26147504

5

Bis(propyl)-cognitin potentiates rehabilitation of treadmill exercise after a transient focal cerebral ischemia, possibly via inhibiting NMDA receptor and regulating VEGF expression.

Ke Z, Hu S, Cui W, Sun J, Zhang S, Mak S, Wang J, Tang J, Pang Y, Han Y, Tong K. Ke Z, et al. Among authors: pang y. Neurochem Int. 2019 Sep;128:143-153. doi: 10.1016/j.neuint.2019.04.016. Epub 2019 Apr 26. Neurochem Int. 2019. PMID: 31034915

6

Substantial neuroprotection against K+ deprivation-induced apoptosis in primary cerebellar granule neurons by novel dimer bis(propyl)-cognitin via the activation of VEGFR-2 signaling pathway.

Hu SQ, Cui W, Xu DP, Mak SH, Tang J, Choi CL, Pang YP, Han YF. Hu SQ, et al. CNS Neurosci Ther. 2013 Oct;19(10):764-72. doi: 10.1111/cns.12141. Epub 2013 Jul 4. CNS Neurosci Ther. 2013. PMID: 23826635 Free PMC article.

7

Robust Neuritogenesis-Promoting Activity by Bis(heptyl)-Cognitin Through the Activation of alpha7-Nicotinic Acetylcholine Receptor/ERK Pathway.

Hu SQ, Cui W, Mak SH, Choi CL, Hu YJ, Li G, Tsim KW, Pang YP, Han YF. Hu SQ, et al. CNS Neurosci Ther. 2015 Jun;21(6):520-9. doi: 10.1111/cns.12401. Epub 2015 Apr 28. CNS Neurosci Ther. 2015. PMID: 25917415 Free PMC article.

8

Dimeric bis (heptyl)-Cognitin Blocks Alzheimer's β-Amyloid Neurotoxicity Via the Inhibition of Aβ Fibrils Formation and Disaggregation of Preformed Fibrils.

Hu SQ, Wang R, Cui W, Mak SH, Li G, Hu YJ, Lee MY, Pang YP, Han YF. Hu SQ, et al. CNS Neurosci Ther. 2015 Dec;21(12):953-61. doi: 10.1111/cns.12472. Epub 2015 Oct 28. CNS Neurosci Ther. 2015. PMID: 26507365 Free PMC article.

9

Novel anti-Alzheimer's dimer Bis(7)-cognitin: cellular and molecular mechanisms of neuroprotection through multiple targets.

Li W, Mak M, Jiang H, Wang Q, Pang Y, Chen K, Han Y. Li W, et al. Among authors: pang y. Neurotherapeutics. 2009 Jan;6(1):187-201. doi: 10.1016/j.nurt.2008.10.040. Neurotherapeutics. 2009. PMID: 19110209 Free PMC article. Review.

10

Pathologically activated neuroprotection via uncompetitive blockade of N-methyl-D-aspartate receptors with fast off-rate by novel multifunctional dimer bis(propyl)-cognitin.

Luo J, Li W, Zhao Y, Fu H, Ma DL, Tang J, Li C, Peoples RW, Li F, Wang Q, Huang P, Xia J, Pang Y, Han Y. Luo J, et al. Among authors: pang y. J Biol Chem. 2010 Jun 25;285(26):19947-58. doi: 10.1074/jbc.M110.111286. Epub 2010 Apr 19. J Biol Chem. 2010. PMID: 20404346 Free PMC article.

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