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Page 1
Therapeutic Use of Vitamin C in Cancer: Physiological Considerations.
Roa FJ, Peña E, Gatica M, Escobar-Acuña K, Saavedra P, Maldonado M, Cuevas ME, Moraga-Cid G, Rivas CI, Muñoz-Montesino C. Roa FJ, et al. Among authors: rivas ci. Front Pharmacol. 2020 Mar 3;11:211. doi: 10.3389/fphar.2020.00211. eCollection 2020. Front Pharmacol. 2020. PMID: 32194425 Free PMC article. Review.
Mechanistic insights and functional determinants of the transport cycle of the ascorbic acid transporter SVCT2. Activation by sodium and absolute dependence on bivalent cations.
Godoy A, Ormazabal V, Moraga-Cid G, Zúñiga FA, Sotomayor P, Barra V, Vasquez O, Montecinos V, Mardones L, Guzmán C, Villagrán M, Aguayo LG, Oñate SA, Reyes AM, Cárcamo JG, Rivas CI, Vera JC. Godoy A, et al. Among authors: rivas ci. J Biol Chem. 2007 Jan 5;282(1):615-24. doi: 10.1074/jbc.M608300200. Epub 2006 Sep 29. J Biol Chem. 2007. PMID: 17012227 Free article.
Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione.
Montecinos V, Guzmán P, Barra V, Villagrán M, Muñoz-Montesino C, Sotomayor K, Escobar E, Godoy A, Mardones L, Sotomayor P, Guzmán C, Vásquez O, Gallardo V, van Zundert B, Bono MR, Oñate SA, Bustamante M, Cárcamo JG, Rivas CI, Vera JC. Montecinos V, et al. Among authors: rivas ci. J Biol Chem. 2007 May 25;282(21):15506-15. doi: 10.1074/jbc.M608361200. Epub 2007 Apr 2. J Biol Chem. 2007. PMID: 17403685 Free article.
Essential role of intracellular glutathione in controlling ascorbic acid transporter expression and function in rat hepatocytes and hepatoma cells.
Mardones L, Zúñiga FA, Villagrán M, Sotomayor K, Mendoza P, Escobar D, González M, Ormazabal V, Maldonado M, Oñate G, Angulo C, Concha II, Reyes AM, Cárcamo JG, Barra V, Vera JC, Rivas CI. Mardones L, et al. Among authors: rivas ci. Free Radic Biol Med. 2012 May 1;52(9):1874-87. doi: 10.1016/j.freeradbiomed.2012.02.017. Epub 2012 Feb 18. Free Radic Biol Med. 2012. PMID: 22348976
Mitochondrial ascorbic acid transport is mediated by a low-affinity form of the sodium-coupled ascorbic acid transporter-2.
Muñoz-Montesino C, Roa FJ, Peña E, González M, Sotomayor K, Inostroza E, Muñoz CA, González I, Maldonado M, Soliz C, Reyes AM, Vera JC, Rivas CI. Muñoz-Montesino C, et al. Among authors: rivas ci. Free Radic Biol Med. 2014 May;70:241-54. doi: 10.1016/j.freeradbiomed.2014.02.021. Epub 2014 Mar 2. Free Radic Biol Med. 2014. PMID: 24594434
Cis-regulatory elements involved in species-specific transcriptional regulation of the SVCT1 gene in rat and human hepatoma cells.
Muñoz A, Villagrán M, Guzmán P, Solíz C, Gatica M, Aylwin C, Sweet K, Maldonado M, Escobar E, Reyes AM, Toledo JR, Sánchez O, Oñate SA, Carlos Vera J, Rivas CI. Muñoz A, et al. Among authors: rivas ci. Free Radic Biol Med. 2015 Aug;85:183-96. doi: 10.1016/j.freeradbiomed.2015.04.024. Epub 2015 Apr 28. Free Radic Biol Med. 2015. PMID: 25933589
Insulin Induces Relaxation and Decreases Hydrogen Peroxide-Induced Vasoconstriction in Human Placental Vascular Bed in a Mechanism Mediated by Calcium-Activated Potassium Channels and L-Arginine/Nitric Oxide Pathways.
Cabrera L, Saavedra A, Rojas S, Cid M, Valenzuela C, Gallegos D, Careaga P, Basualto E, Haensgen A, Peña E, Rivas C, Vera JC, Gallardo V, Zúñiga L, Escudero C, Sobrevia L, Wareing M, González M. Cabrera L, et al. Front Physiol. 2016 Nov 22;7:529. doi: 10.3389/fphys.2016.00529. eCollection 2016. Front Physiol. 2016. PMID: 27920724 Free PMC article.
Sustained blockade of ascorbic acid transport associated with marked SVCT1 loss in rat hepatocytes containing increased ascorbic acid levels after partial hepatectomy.
Maldonado M, Inostroza E, Peña E, Moncada N, Mardones L, Medina JL, Muñoz A, Gatica M, Villagrán M, Escobar E, Mendoza P, Roa FJ, González M, Guzmán P, Gutiérrez-Castro FA, Sweet K, Muñoz-Montesino C, Vera JC, Rivas CI. Maldonado M, et al. Among authors: rivas ci. Free Radic Biol Med. 2017 Jul;108:655-667. doi: 10.1016/j.freeradbiomed.2017.04.006. Epub 2017 Apr 15. Free Radic Biol Med. 2017. PMID: 28419867
Increased expression of mitochondrial sodium-coupled ascorbic acid transporter-2 (mitSVCT2) as a central feature in breast cancer.
Peña E, Roa FJ, Inostroza E, Sotomayor K, González M, Gutierrez-Castro FA, Maurin M, Sweet K, Labrousse C, Gatica M, Aylwin CF, Mendoza P, Maldonado M, Delgado C, Madariaga J, Panes J, Silva-Grecchi T, Concha II, Moraga-Cid G, Reyes AM, Muñoz-Montesino C, Vera JC, Rivas CI. Peña E, et al. Among authors: rivas ci. Free Radic Biol Med. 2019 May 1;135:283-292. doi: 10.1016/j.freeradbiomed.2019.03.015. Epub 2019 Mar 19. Free Radic Biol Med. 2019. PMID: 30902760
GLUT1 and GLUT8 support lactose synthesis in Golgi of murine mammary epithelial cells.
Villagrán M, Muñoz M, Inostroza E, Venegas C, Ruminot I, Parra-Valencia E, Maldonado M, Del Pozo R, Rivas CI, Vera JC, Mardones L. Villagrán M, et al. Among authors: rivas ci. J Physiol Biochem. 2019 Jun;75(2):209-215. doi: 10.1007/s13105-019-00679-3. Epub 2019 Apr 24. J Physiol Biochem. 2019. PMID: 31020623
79 results