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DDX3 inhibitors show antiviral activity against positive-sense single-stranded RNA viruses but not against negative-sense single-stranded RNA viruses: The coxsackie B model.
Quaranta P, Lottini G, Chesi G, Contrafatto F, Russotto R, Macera L, Lai M, Spezia PG, Brai A, Botta M, Freer G, Pistello M. Quaranta P, et al. Among authors: botta m. Antiviral Res. 2020 Jun;178:104750. doi: 10.1016/j.antiviral.2020.104750. Epub 2020 Mar 20. Antiviral Res. 2020. PMID: 32205137
Human DDX3 protein is a valuable target to develop broad spectrum antiviral agents.
Brai A, Fazi R, Tintori C, Zamperini C, Bugli F, Sanguinetti M, Stigliano E, Esté J, Badia R, Franco S, Martinez MA, Martinez JP, Meyerhans A, Saladini F, Zazzi M, Garbelli A, Maga G, Botta M. Brai A, et al. Among authors: botta m. Proc Natl Acad Sci U S A. 2016 May 10;113(19):5388-93. doi: 10.1073/pnas.1522987113. Epub 2016 Apr 26. Proc Natl Acad Sci U S A. 2016. PMID: 27118832 Free PMC article.
Synthesis and Antiviral Activity of Novel 1,3,4-Thiadiazole Inhibitors of DDX3X.
Brai A, Ronzini S, Riva V, Botta L, Zamperini C, Borgini M, Trivisani CI, Garbelli A, Pennisi C, Boccuto A, Saladini F, Zazzi M, Maga G, Botta M. Brai A, et al. Among authors: botta m, botta l. Molecules. 2019 Nov 4;24(21):3988. doi: 10.3390/molecules24213988. Molecules. 2019. PMID: 31690062 Free PMC article.
DDX3X Helicase Inhibitors as a New Strategy To Fight the West Nile Virus Infection.
Brai A, Martelli F, Riva V, Garbelli A, Fazi R, Zamperini C, Pollutri A, Falsitta L, Ronzini S, Maccari L, Maga G, Giannecchini S, Botta M. Brai A, et al. Among authors: botta m. J Med Chem. 2019 Mar 14;62(5):2333-2347. doi: 10.1021/acs.jmedchem.8b01403. Epub 2019 Feb 21. J Med Chem. 2019. PMID: 30721061
Novel broad spectrum virucidal molecules against enveloped viruses.
Cagno V, Tintori C, Civra A, Cavalli R, Tiberi M, Botta L, Brai A, Poli G, Tapparel C, Lembo D, Botta M. Cagno V, et al. Among authors: botta m, botta l. PLoS One. 2018 Dec 7;13(12):e0208333. doi: 10.1371/journal.pone.0208333. eCollection 2018. PLoS One. 2018. PMID: 30532192 Free PMC article.
DDX3X inhibitors, an effective way to overcome HIV-1 resistance targeting host proteins.
Brai A, Riva V, Saladini F, Zamperini C, Trivisani CI, Garbelli A, Pennisi C, Giannini A, Boccuto A, Bugli F, Martini M, Sanguinetti M, Zazzi M, Dreassi E, Botta M, Maga G. Brai A, et al. Among authors: botta m. Eur J Med Chem. 2020 Aug 15;200:112319. doi: 10.1016/j.ejmech.2020.112319. Epub 2020 May 7. Eur J Med Chem. 2020. PMID: 32446036 Free article.
Targeting DDX3X Helicase Activity with BA103 Shows Promising Therapeutic Effects in Preclinical Glioblastoma Models.
Brai A, Riva V, Clementi L, Falsitta L, Zamperini C, Sinigiani V, Festuccia C, Sabetta S, Aiello D, Roselli C, Garbelli A, Trivisani CI, Maccari L, Bugli F, Sanguinetti M, Calandro P, Chiariello M, Quaranta P, Botta L, Angelucci A, Maga G, Botta M. Brai A, et al. Among authors: botta m, botta l. Cancers (Basel). 2021 Nov 7;13(21):5569. doi: 10.3390/cancers13215569. Cancers (Basel). 2021. PMID: 34771731 Free PMC article.
734 results