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Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.
Daffis S, Balsitis S, Chamberlain J, Zheng J, Santos R, Rowe W, Ramakrishnan D, Pattabiraman D, Spurlock S, Chu R, Kang D, Mish M, Ramirez R, Li L, Li B, Ma S, Hung M, Voitenleitner C, Yon C, Suresh M, Menne S, Cote P, Delaney WE 4th, Mackman R, Fletcher SP. Daffis S, et al. Among authors: ramakrishnan d. Hepatology. 2021 Jan;73(1):53-67. doi: 10.1002/hep.31255. Epub 2020 Nov 27. Hepatology. 2021. PMID: 32246499 Free PMC article.
The Smc5/6 Complex Restricts HBV when Localized to ND10 without Inducing an Innate Immune Response and Is Counteracted by the HBV X Protein Shortly after Infection.
Niu C, Livingston CM, Li L, Beran RK, Daffis S, Ramakrishnan D, Burdette D, Peiser L, Salas E, Ramos H, Yu M, Cheng G, Strubin M, Delaney WE IV, Fletcher SP. Niu C, et al. Among authors: ramakrishnan d. PLoS One. 2017 Jan 17;12(1):e0169648. doi: 10.1371/journal.pone.0169648. eCollection 2017. PLoS One. 2017. PMID: 28095508 Free PMC article.
Hepatitis B Virus X Protein Function Requires Zinc Binding.
Ramakrishnan D, Xing W, Beran RK, Chemuru S, Rohrs H, Niedziela-Majka A, Marchand B, Mehra U, Zábranský A, Doležal M, Hubálek M, Pichová I, Gross ML, Kwon HJ, Fletcher SP. Ramakrishnan D, et al. J Virol. 2019 Jul 30;93(16):e00250-19. doi: 10.1128/JVI.00250-19. Print 2019 Aug 15. J Virol. 2019. PMID: 31167910 Free PMC article.
Therapeutic Potential of TLR8 Agonist GS-9688 (Selgantolimod) in Chronic Hepatitis B: Remodeling of Antiviral and Regulatory Mediators.
Amin OE, Colbeck EJ, Daffis S, Khan S, Ramakrishnan D, Pattabiraman D, Chu R, Micolochick Steuer H, Lehar S, Peiser L, Palazzo A, Frey C, Davies J, Javanbakht H, Rosenberg WMC, Fletcher SP, Maini MK, Pallett LJ. Amin OE, et al. Among authors: ramakrishnan d. Hepatology. 2021 Jul;74(1):55-71. doi: 10.1002/hep.31695. Epub 2021 Jun 20. Hepatology. 2021. PMID: 33368377 Free PMC article. Clinical Trial.
Smc5/6 silences episomal transcription by a three-step function.
Abdul F, Diman A, Baechler B, Ramakrishnan D, Kornyeyev D, Beran RK, Fletcher SP, Strubin M. Abdul F, et al. Among authors: ramakrishnan d. Nat Struct Mol Biol. 2022 Sep;29(9):922-931. doi: 10.1038/s41594-022-00829-0. Epub 2022 Sep 12. Nat Struct Mol Biol. 2022. PMID: 36097294
The NF-κB RelB protein is an oncogenic driver of mesenchymal glioma.
Lee DW, Ramakrishnan D, Valenta J, Parney IF, Bayless KJ, Sitcheran R. Lee DW, et al. Among authors: ramakrishnan d. PLoS One. 2013;8(2):e57489. doi: 10.1371/journal.pone.0057489. Epub 2013 Feb 25. PLoS One. 2013. PMID: 23451236 Free PMC article.
Enhancing clinical decision-making: An externally validated machine learning model for predicting isocitrate dehydrogenase mutation in gliomas using radiomics from presurgical magnetic resonance imaging.
Lost J, Ashraf N, Jekel L, von Reppert M, Tillmanns N, Willms K, Merkaj S, Petersen GC, Avesta A, Ramakrishnan D, Omuro A, Nabavizadeh A, Bakas S, Bousabarah K, Lin M, Aneja S, Sabel M, Aboian M. Lost J, et al. Among authors: ramakrishnan d. Neurooncol Adv. 2024 Oct 3;6(1):vdae157. doi: 10.1093/noajnl/vdae157. eCollection 2024 Jan-Dec. Neurooncol Adv. 2024. PMID: 39659829 Free PMC article.
72 results