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Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.
Daffis S, Balsitis S, Chamberlain J, Zheng J, Santos R, Rowe W, Ramakrishnan D, Pattabiraman D, Spurlock S, Chu R, Kang D, Mish M, Ramirez R, Li L, Li B, Ma S, Hung M, Voitenleitner C, Yon C, Suresh M, Menne S, Cote P, Delaney WE 4th, Mackman R, Fletcher SP. Daffis S, et al. Among authors: santos r. Hepatology. 2021 Jan;73(1):53-67. doi: 10.1002/hep.31255. Epub 2020 Nov 27. Hepatology. 2021. PMID: 32246499 Free PMC article.
Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
Mackman RL, Mish M, Chin G, Perry JK, Appleby T, Aktoudianakis V, Metobo S, Pyun P, Niu C, Daffis S, Yu H, Zheng J, Villasenor AG, Zablocki J, Chamberlain J, Jin H, Lee G, Suekawa-Pirrone K, Santos R, Delaney WE 4th, Fletcher SP. Mackman RL, et al. Among authors: santos r. J Med Chem. 2020 Sep 24;63(18):10188-10203. doi: 10.1021/acs.jmedchem.0c00100. Epub 2020 Jun 3. J Med Chem. 2020. PMID: 32407112
Discovery of a Potent and Orally Bioavailable Cyclophilin Inhibitor Derived from the Sanglifehrin Macrocycle.
Mackman RL, Steadman VA, Dean DK, Jansa P, Poullennec KG, Appleby T, Austin C, Blakemore CA, Cai R, Cannizzaro C, Chin G, Chiva JC, Dunbar NA, Fliri H, Highton AJ, Hui H, Ji M, Jin H, Karki K, Keats AJ, Lazarides L, Lee YJ, Liclican A, Mish M, Murray B, Pettit SB, Pyun P, Sangi M, Santos R, Sanvoisin J, Schmitz U, Schrier A, Siegel D, Sperandio D, Stepan G, Tian Y, Watt GM, Yang H, Schultz BE. Mackman RL, et al. Among authors: santos r. J Med Chem. 2018 Nov 8;61(21):9473-9499. doi: 10.1021/acs.jmedchem.8b00802. Epub 2018 Aug 22. J Med Chem. 2018. PMID: 30074795
Characterization and analysis of the bioactivity of the Piper rivinoides Kunth essential oil and its components myristicin and elemicin, against opportunistic fungal pathogens.
Fonseca VJA, Castro Dos Santos S, Carneiro JNP, Dos Santos ATL, de Freitas MA, de Carvalho NKG, Dos Santos Silva F, Dos Santos AG, Menêses AVS, Farias NS, Dos Santos RP, Rebelo RA, Rau M, da Silva LE, Amaral WD, da Costa JGM, de Menezes IRA, Morais-Braga MFB. Fonseca VJA, et al. Among authors: dos santos rp. Microb Pathog. 2024 Dec 20;199:107242. doi: 10.1016/j.micpath.2024.107242. Online ahead of print. Microb Pathog. 2024. PMID: 39708980
Environmental Crisis and the Emergence of the Oropouche: A Potential Public Health Problem.
Barreto MDS, Santos RS, Santana LADM, Gopalsamy RG, Hariharan G, Brasileiro BF, Gurgel RQ, Correia D, Trento CL, Borges LP. Barreto MDS, et al. Among authors: santos rs. Rev Soc Bras Med Trop. 2024 Dec 16;57:e011032024. doi: 10.1590/0037-8682-0295-2024. eCollection 2024. Rev Soc Bras Med Trop. 2024. PMID: 39699548 Free PMC article. No abstract available.
Identifying candidate genes for sugar accumulation in sugarcane: an integrative approach.
Martins MLT, Sforça DA, Dos Santos LP, Pimenta RJG, Mancini MC, Aono AH, Cardoso-Silva CB, Vautrin S, Bellec A, Dos Santos RV, Bérgès H, da Silva CC, de Souza AP. Martins MLT, et al. Among authors: dos santos rv. BMC Genomics. 2024 Dec 18;25(1):1201. doi: 10.1186/s12864-024-11089-1. BMC Genomics. 2024. PMID: 39695384 Free PMC article.
Relationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Reynolds HR, Page CB, Shaw LJ, Berman DS, Chaitman BR, Picard MH, Kwong RY, Min JK, Leipsic J, Mancini GBJ, Budoff MJ, Hague CJ, Senior R, Szwed H, Bhargava B, Celutkiene J, Gadkari M, Bainey KR, Doerr R, Ramos RB, Ong P, Naik SR, Steg PG, Goetschalckx K, Chow BJW, Scherrer-Crosbie M, Phillips L, Mark DB, Spertus JA, Alexander KP, O'Brien SM, Boden WE, Bangalore S, Stone GW, Maron DJ, Hochman JS; ISCHEMIA Research Group. Reynolds HR, et al. Circ Cardiovasc Interv. 2024 Dec;17(12):e013743. doi: 10.1161/CIRCINTERVENTIONS.123.013743. Epub 2024 Dec 17. Circ Cardiovasc Interv. 2024. PMID: 39689188 Clinical Trial.
6,839 results