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Effects of itraconazole and rifampicin on the single-dose pharmacokinetics of the nonsteroidal mineralocorticoid receptor blocker esaxerenone in healthy Japanese subjects.
Kirigaya Y, Shiramoto M, Ishizuka T, Uchimaru H, Irie S, Kato M, Shimizu T, Nakatsu T, Nishikawa Y, Ishizuka H. Kirigaya Y, et al. Among authors: uchimaru h. Br J Clin Pharmacol. 2020 Oct;86(10):2070-2079. doi: 10.1111/bcp.14302. Epub 2020 May 13. Br J Clin Pharmacol. 2020. PMID: 32250463 Free PMC article.
SLCO1B1 (OATP1B1, an uptake transporter) and ABCG2 (BCRP, an efflux transporter) variant alleles and pharmacokinetics of pitavastatin in healthy volunteers.
Ieiri I, Suwannakul S, Maeda K, Uchimaru H, Hashimoto K, Kimura M, Fujino H, Hirano M, Kusuhara H, Irie S, Higuchi S, Sugiyama Y. Ieiri I, et al. Among authors: uchimaru h. Clin Pharmacol Ther. 2007 Nov;82(5):541-7. doi: 10.1038/sj.clpt.6100190. Epub 2007 Apr 25. Clin Pharmacol Ther. 2007. PMID: 17460607 Clinical Trial.
Measurement of drug concentration in the stomach after intragastric administration of drug solution to healthy volunteers: analysis of intragastric fluid dynamics and drug absorption.
Yamashita S, Kataoka M, Higashino H, Sakuma S, Sakamoto T, Uchimaru H, Tsukikawa H, Shiramoto M, Uchiyama H, Tachiki H, Irie S. Yamashita S, et al. Among authors: uchimaru h. Pharm Res. 2013 Apr;30(4):951-8. doi: 10.1007/s11095-012-0931-1. Epub 2012 Nov 21. Pharm Res. 2013. PMID: 23179782 Clinical Trial.