Saxena A - Search Results

1

Proline 285 is integral for the reactivation of organophosphate-inhibited human butyrylcholinesterase by 2-PAM.

diTargiani RC, Belinskaya T, Tipparaju P, Lockridge O, Saxena A. diTargiani RC, et al. Among authors: saxena a. Chem Biol Interact. 2020 Jun 1;324:109092. doi: 10.1016/j.cbi.2020.109092. Epub 2020 Apr 10. Chem Biol Interact. 2020. PMID: 32278739

2

Immunochemical characterization of anti-acetylcholinesterase inhibitory monoclonal antibodies.

Gentry MK, Saxena A, Ashani Y, Doctor BP. Gentry MK, et al. Among authors: saxena a. Chem Biol Interact. 1993 Jun;87(1-3):227-31. doi: 10.1016/0009-2797(93)90046-2. Chem Biol Interact. 1993. PMID: 7688272

3

Differences in active site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.

Saxena A, Redman AM, Jiang X, Lockridge O, Doctor BP. Saxena A, et al. Biochemistry. 1997 Dec 2;36(48):14642-51. doi: 10.1021/bi971425+. Biochemistry. 1997. PMID: 9398183

4

The pH dependence of dealkylation in soman-inhibited cholinesterases and their mutants: further evidence for a push-pull mechanism.

Saxena A, Viragh C, Frazier DS, Kovach IM, Maxwell DM, Lockridge O, Doctor BP. Saxena A, et al. Biochemistry. 1998 Oct 27;37(43):15086-96. doi: 10.1021/bi980917z. Biochemistry. 1998. PMID: 9790671

5

Differences in active-site gorge dimensions of cholinesterases revealed by binding of inhibitors to human butyrylcholinesterase.

Saxena A, Redman AM, Jiang X, Lockridge O, Doctor BP. Saxena A, et al. Chem Biol Interact. 1999 May 14;119-120:61-9. doi: 10.1016/s0009-2797(99)00014-9. Chem Biol Interact. 1999. PMID: 10421439

6

Role of edrophonium in prevention of the re-inhibition of acetylcholinesterase by phosphorylated oxime.

Luo C, Saxena A, Ashani Y, Leader H, Radić Z, Taylor P, Doctor BP. Luo C, et al. Among authors: saxena a. Chem Biol Interact. 1999 May 14;119-120:129-35. doi: 10.1016/s0009-2797(99)00021-6. Chem Biol Interact. 1999. PMID: 10421446 Review.

7

Improvements in scavenger protection against organophosphorus agents by modification of cholinesterases.

Maxwell DM, Saxena A, Gordon RK, Doctor BP. Maxwell DM, et al. Among authors: saxena a. Chem Biol Interact. 1999 May 14;119-120:419-28. doi: 10.1016/s0009-2797(99)00054-x. Chem Biol Interact. 1999. PMID: 10421479 Review.

8

Two possible orientations of the HI-6 molecule in the reactivation of organophosphate-inhibited acetylcholinesterase.

Luo C, Leader H, Radic Z, Maxwell DM, Taylor P, Doctor BP, Saxena A. Luo C, et al. Among authors: saxena a. Biochem Pharmacol. 2003 Aug 1;66(3):387-92. doi: 10.1016/s0006-2952(03)00237-5. Biochem Pharmacol. 2003. PMID: 12907237

9

Aromatic amino-acid residues at the active and peripheral anionic sites control the binding of E2020 (Aricept) to cholinesterases.

Saxena A, Fedorko JM, Vinayaka CR, Medhekar R, Radić Z, Taylor P, Lockridge O, Doctor BP. Saxena A, et al. Eur J Biochem. 2003 Nov;270(22):4447-58. doi: 10.1046/j.1432-1033.2003.03837.x. Eur J Biochem. 2003. PMID: 14622273 Free article.

10

Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.

Campiani G, Fattorusso C, Butini S, Gaeta A, Agnusdei M, Gemma S, Persico M, Catalanotti B, Savini L, Nacci V, Novellino E, Holloway HW, Greig NH, Belinskaya T, Fedorko JM, Saxena A. Campiani G, et al. Among authors: saxena a. J Med Chem. 2005 Mar 24;48(6):1919-29. doi: 10.1021/jm049510k. J Med Chem. 2005. PMID: 15771436

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