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GPCR-G Protein-β-Arrestin Super-Complex Mediates Sustained G Protein Signaling.
Thomsen ARB, Plouffe B, Cahill TJ 3rd, Shukla AK, Tarrasch JT, Dosey AM, Kahsai AW, Strachan RT, Pani B, Mahoney JP, Huang L, Breton B, Heydenreich FM, Sunahara RK, Skiniotis G, Bouvier M, Lefkowitz RJ. Thomsen ARB, et al. Among authors: plouffe b. Cell. 2016 Aug 11;166(4):907-919. doi: 10.1016/j.cell.2016.07.004. Epub 2016 Aug 4. Cell. 2016. PMID: 27499021 Free PMC article.
Distinct conformations of GPCR-β-arrestin complexes mediate desensitization, signaling, and endocytosis.
Cahill TJ 3rd, Thomsen AR, Tarrasch JT, Plouffe B, Nguyen AH, Yang F, Huang LY, Kahsai AW, Bassoni DL, Gavino BJ, Lamerdin JE, Triest S, Shukla AK, Berger B, Little J 4th, Antar A, Blanc A, Qu CX, Chen X, Kawakami K, Inoue A, Aoki J, Steyaert J, Sun JP, Bouvier M, Skiniotis G, Lefkowitz RJ. Cahill TJ 3rd, et al. Among authors: plouffe b. Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2562-2567. doi: 10.1073/pnas.1701529114. Epub 2017 Feb 21. Proc Natl Acad Sci U S A. 2017. PMID: 28223524 Free PMC article.
Structural Elements Directing G Proteins and β-Arrestin Interactions with the Human Melatonin Type 2 Receptor Revealed by Natural Variants.
Plouffe B, Karamitri A, Flock T, Gallion JM, Houston S, Daly CA, Bonnefond A, Guillaume JL, Le Gouill C, Froguel P, Lichtarge O, Deupi X, Jockers R, Bouvier M. Plouffe B, et al. ACS Pharmacol Transl Sci. 2022 Jan 25;5(2):89-101. doi: 10.1021/acsptsci.1c00239. eCollection 2022 Feb 11. ACS Pharmacol Transl Sci. 2022. PMID: 35846981 Free PMC article.
Identification of Key Regions Mediating Human Melatonin Type 1 Receptor Functional Selectivity Revealed by Natural Variants.
Hegron A, Huh E, Deupi X, Sokrat B, Gao W, Le Gouill C, Canouil M, Boissel M, Charpentier G, Roussel R, Balkau B, Froguel P, Plouffe B, Bonnefond A, Lichtarge O, Jockers R, Bouvier M. Hegron A, et al. Among authors: plouffe b. ACS Pharmacol Transl Sci. 2021 Sep 1;4(5):1614-1627. doi: 10.1021/acsptsci.1c00157. eCollection 2021 Oct 8. ACS Pharmacol Transl Sci. 2021. PMID: 34661078 Free PMC article.
q signalling from endosomes: A new conundrum.
Daly C, Plouffe B. Daly C, et al. Among authors: plouffe b. Br J Pharmacol. 2023 Sep 22. doi: 10.1111/bph.16248. Online ahead of print. Br J Pharmacol. 2023. PMID: 37740273 Free article. Review.
51 results