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Allosteric small molecule modulators of nuclear receptors.
Meijer FA, Leijten-van de Gevel IA, de Vries RMJM, Brunsveld L. Meijer FA, et al. Among authors: brunsveld l. Mol Cell Endocrinol. 2019 Apr 5;485:20-34. doi: 10.1016/j.mce.2019.01.022. Epub 2019 Jan 28. Mol Cell Endocrinol. 2019. PMID: 30703487 Free article. Review.
Modulators of protein-protein interactions.
Milroy LG, Grossmann TN, Hennig S, Brunsveld L, Ottmann C. Milroy LG, et al. Among authors: brunsveld l. Chem Rev. 2014 May 14;114(9):4695-748. doi: 10.1021/cr400698c. Epub 2014 Apr 15. Chem Rev. 2014. PMID: 24735440 Review. No abstract available.
Identification of an allosteric binding site for RORγt inhibition.
Scheepstra M, Leysen S, van Almen GC, Miller JR, Piesvaux J, Kutilek V, van Eenennaam H, Zhang H, Barr K, Nagpal S, Soisson SM, Kornienko M, Wiley K, Elsen N, Sharma S, Correll CC, Trotter BW, van der Stelt M, Oubrie A, Ottmann C, Parthasarathy G, Brunsveld L. Scheepstra M, et al. Among authors: brunsveld l. Nat Commun. 2015 Dec 7;6:8833. doi: 10.1038/ncomms9833. Nat Commun. 2015. PMID: 26640126 Free PMC article.
Ligand Dependent Switch from RXR Homo- to RXR-NURR1 Heterodimerization.
Scheepstra M, Andrei SA, de Vries RMJM, Meijer FA, Ma JN, Burstein ES, Olsson R, Ottmann C, Milroy LG, Brunsveld L. Scheepstra M, et al. Among authors: brunsveld l. ACS Chem Neurosci. 2017 Sep 20;8(9):2065-2077. doi: 10.1021/acschemneuro.7b00216. Epub 2017 Jul 24. ACS Chem Neurosci. 2017. PMID: 28691794 Free PMC article.
Conjugated Protein Domains as Engineered Scaffold Proteins.
Lemmens LJM, Ottmann C, Brunsveld L. Lemmens LJM, et al. Among authors: brunsveld l. Bioconjug Chem. 2020 Jun 17;31(6):1596-1603. doi: 10.1021/acs.bioconjchem.0c00183. Epub 2020 May 20. Bioconjug Chem. 2020. PMID: 32374984 Free PMC article. Review.
197 results