Helfrich W - Search Results

1

Modular Medical Imaging Agents Based on Azide-Alkyne Huisgen Cycloadditions: Synthesis and Pre-Clinical Evaluation of ¹⁸ F-Labeled PSMA-Tracers for Prostate Cancer Imaging.

Böhmer VI, Szymanski W, van den Berg KO, Mulder C, Kobauri P, Helbert H, van der Born D, Reeβing F, Huizing A, Klopstra M, Samplonius DF, Antunes IF, Sijbesma JWA, Luurtsema G, Helfrich W, Visser TJ, Feringa BL, Elsinga PH. Böhmer VI, et al. Among authors: helfrich w. Chemistry. 2020 Aug 21;26(47):10871-10881. doi: 10.1002/chem.202001795. Epub 2020 Jul 21. Chemistry. 2020. PMID: 32315486 Free PMC article.

2

Target cell-restricted and -enhanced apoptosis induction by a scFv:sTRAIL fusion protein with specificity for the pancarcinoma-associated antigen EGP2.

Bremer E, Kuijlen J, Samplonius D, Walczak H, de Leij L, Helfrich W. Bremer E, et al. Among authors: helfrich w. Int J Cancer. 2004 Mar 20;109(2):281-90. doi: 10.1002/ijc.11702. Int J Cancer. 2004. PMID: 14750182

3

Exceptionally potent anti-tumor bystander activity of an scFv:sTRAIL fusion protein with specificity for EGP2 toward target antigen-negative tumor cells.

Bremer E, Samplonius D, Kroesen BJ, van Genne L, de Leij L, Helfrich W. Bremer E, et al. Among authors: helfrich w. Neoplasia. 2004 Sep-Oct;6(5):636-45. doi: 10.1593/neo.04229. Neoplasia. 2004. PMID: 15548373 Free PMC article.

4

Simultaneous inhibition of epidermal growth factor receptor (EGFR) signaling and enhanced activation of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor-mediated apoptosis induction by an scFv:sTRAIL fusion protein with specificity for human EGFR.

Bremer E, Samplonius DF, van Genne L, Dijkstra MH, Kroesen BJ, de Leij LF, Helfrich W. Bremer E, et al. Among authors: helfrich w. J Biol Chem. 2005 Mar 18;280(11):10025-33. doi: 10.1074/jbc.M413673200. Epub 2005 Jan 11. J Biol Chem. 2005. PMID: 15644326 Free article.

5

Target cell-restricted apoptosis induction of acute leukemic T cells by a recombinant tumor necrosis factor-related apoptosis-inducing ligand fusion protein with specificity for human CD7.

Bremer E, Samplonius DF, Peipp M, van Genne L, Kroesen BJ, Fey GH, Gramatzki M, de Leij LF, Helfrich W. Bremer E, et al. Among authors: helfrich w. Cancer Res. 2005 Apr 15;65(8):3380-8. doi: 10.1158/0008-5472.CAN-04-2756. Cancer Res. 2005. PMID: 15833872

6

CD7-restricted activation of Fas-mediated apoptosis: a novel therapeutic approach for acute T-cell leukemia.

Bremer E, ten Cate B, Samplonius DF, de Leij LF, Helfrich W. Bremer E, et al. Among authors: helfrich w. Blood. 2006 Apr 1;107(7):2863-70. doi: 10.1182/blood-2005-07-2929. Epub 2005 Dec 6. Blood. 2006. PMID: 16332967 Free article.

7

The efficacy of alginate encapsulated CHO-K1 single chain-TRAIL producer cells in the treatment of brain tumors.

Kuijlen JM, de Haan BJ, Helfrich W, de Boer JF, Samplonius D, Mooij JJ, de Vos P. Kuijlen JM, et al. Among authors: helfrich w. J Neurooncol. 2006 May;78(1):31-9. doi: 10.1007/s11060-005-9071-3. Epub 2006 Apr 6. J Neurooncol. 2006. PMID: 16598433

8

The histone deacetylase inhibitor valproic acid potently augments gemtuzumab ozogamicin-induced apoptosis in acute myeloid leukemic cells.

ten Cate B, Samplonius DF, Bijma T, de Leij LF, Helfrich W, Bremer E. ten Cate B, et al. Among authors: helfrich w. Leukemia. 2007 Feb;21(2):248-52. doi: 10.1038/sj.leu.2404477. Epub 2006 Nov 23. Leukemia. 2007. PMID: 17122863

9

Superior activity of fusion protein scFvRit:sFasL over cotreatment with rituximab and Fas agonists.

Bremer E, ten Cate B, Samplonius DF, Mueller N, Wajant H, Stel AJ, Chamuleau M, van de Loosdrecht AA, Stieglmaier J, Fey GH, Helfrich W. Bremer E, et al. Among authors: helfrich w. Cancer Res. 2008 Jan 15;68(2):597-604. doi: 10.1158/0008-5472.CAN-07-5171. Cancer Res. 2008. PMID: 18199557

10

Targeted delivery of a designed sTRAIL mutant results in superior apoptotic activity towards EGFR-positive tumor cells.

Bremer E, de Bruyn M, Samplonius DF, Bijma T, ten Cate B, de Leij LF, Helfrich W. Bremer E, et al. Among authors: helfrich w. J Mol Med (Berl). 2008 Aug;86(8):909-24. doi: 10.1007/s00109-008-0348-9. Epub 2008 May 27. J Mol Med (Berl). 2008. PMID: 18504532 Free PMC article.

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