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Pharmacological Characterization of the Microsomal Prostaglandin E2 Synthase-1 Inhibitor AF3485 In Vitro and In Vivo.
Di Francesco L, Bruno A, Ricciotti E, Tacconelli S, Dovizio M, Guillem-Llobat P, Alisi MA, Garrone B, Coletta I, Mangano G, Milanese C, FitzGerald GA, Patrignani P. Di Francesco L, et al. Among authors: mangano g. Front Pharmacol. 2020 Apr 2;11:374. doi: 10.3389/fphar.2020.00374. eCollection 2020. Front Pharmacol. 2020. PMID: 32317963 Free PMC article.
Effects of AF3442 [N-(9-ethyl-9H-carbazol-3-yl)-2-(trifluoromethyl)benzamide], a novel inhibitor of human microsomal prostaglandin E synthase-1, on prostanoid biosynthesis in human monocytes in vitro.
Bruno A, Di Francesco L, Coletta I, Mangano G, Alisi MA, Polenzani L, Milanese C, Anzellotti P, Ricciotti E, Dovizio M, Di Francesco A, Tacconelli S, Capone ML, Patrignani P. Bruno A, et al. Among authors: mangano g. Biochem Pharmacol. 2010 Apr 1;79(7):974-81. doi: 10.1016/j.bcp.2009.11.011. Epub 2009 Nov 27. Biochem Pharmacol. 2010. PMID: 19925781
Discovery and pharmacological profile of new 1H-indazole-3-carboxamide and 2H-pyrrolo[3,4-c]quinoline derivatives as selective serotonin 4 receptor ligands.
Furlotti G, Alisi MA, Apicella C, Capezzone de Joannon A, Cazzolla N, Costi R, Cuzzucoli Crucitti G, Garrone B, Iacovo A, Magarò G, Mangano G, Miele G, Ombrato R, Pescatori L, Polenzani L, Rosi F, Vitiello M, Di Santo R. Furlotti G, et al. Among authors: mangano g. J Med Chem. 2012 Nov 26;55(22):9446-66. doi: 10.1021/jm300573d. Epub 2012 Oct 24. J Med Chem. 2012. PMID: 23043420
Targeting Serotonin 2A and Adrenergic α1 Receptors for Ocular Antihypertensive Agents: Discovery of 3,4-Dihydropyrazino[1,2-b]indazol-1(2H)-one Derivatives.
Furlotti G, Alisi MA, Cazzolla N, Ceccacci F, Garrone B, Gasperi T, La Bella A, Leonelli F, Loreto MA, Magarò G, Mangano G, Bettolo RM, Masini E, Miceli M, Migneco LM, Vitiello M. Furlotti G, et al. Among authors: mangano g. ChemMedChem. 2018 Aug 10;13(15):1597-1607. doi: 10.1002/cmdc.201800199. Epub 2018 Jul 9. ChemMedChem. 2018. PMID: 29873449
Optimization of Indazole-Based GSK-3 Inhibitors with Mitigated hERG Issue and In Vivo Activity in a Mood Disorder Model.
Prati F, Buonfiglio R, Furlotti G, Cavarischia C, Mangano G, Picollo R, Oggianu L, di Matteo A, Olivieri S, Bovi G, Porceddu PF, Reggiani A, Garrone B, Di Giorgio FP, Ombrato R. Prati F, et al. Among authors: mangano g. ACS Med Chem Lett. 2020 Mar 24;11(5):825-831. doi: 10.1021/acsmedchemlett.9b00633. eCollection 2020 May 14. ACS Med Chem Lett. 2020. PMID: 32435391 Free PMC article.
125 results