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An anti-inflammatory eicosanoid switch mediates the suppression of type-2 inflammation by helminth larval products.
de Los Reyes Jiménez M, Lechner A, Alessandrini F, Bohnacker S, Schindela S, Trompette A, Haimerl P, Thomas D, Henkel F, Mourão A, Geerlof A, da Costa CP, Chaker AM, Brüne B, Nüsing R, Jakobsson PJ, Nockher WA, Feige MJ, Haslbeck M, Ohnmacht C, Marsland BJ, Voehringer D, Harris NL, Schmidt-Weber CB, Esser-von Bieren J. de Los Reyes Jiménez M, et al. Among authors: da costa cp. Sci Transl Med. 2020 Apr 22;12(540):eaay0605. doi: 10.1126/scitranslmed.aay0605. Sci Transl Med. 2020. PMID: 32321863
Human interleukin-12α and EBI3 are cytokines with anti-inflammatory functions.
Hildenbrand K, Bohnacker S, Menon PR, Kerle A, Prodjinotho UF, Hartung F, Strasser PC, Catici DAM, Rührnößl F, Haslbeck M, Schumann K, Müller SI, da Costa CP, Esser-von Bieren J, Feige MJ. Hildenbrand K, et al. Among authors: da costa cp. Sci Adv. 2023 Oct 27;9(43):eadg6874. doi: 10.1126/sciadv.adg6874. Epub 2023 Oct 25. Sci Adv. 2023. PMID: 37878703 Free PMC article.
A helminth enzyme subverts macrophage-mediated immunity by epigenetic targeting of prostaglandin synthesis.
Bohnacker S, Henkel FDR, Hartung F, Geerlof A, Riemer S, Prodjinotho UF, Salah EB, Mourão ASD, Bohn S, Teder T, Thomas D, Gurke R, Boeckel C, Ud-Dean M, König AC, Quaranta A, Alessandrini F, Lechner A, Spitzlberger B, Kabat AM, Pearce E, Haeggström JZ, Hauck SM, Wheelock CE, Jakobsson PJ, Sattler M, Voehringer D, Feige MJ, da Costa CP, Esser-von Bieren J. Bohnacker S, et al. Among authors: da costa cp. Sci Immunol. 2024 Dec 6;9(102):eadl1467. doi: 10.1126/sciimmunol.adl1467. Epub 2024 Dec 6. Sci Immunol. 2024. PMID: 39642243
60 results