Varejão N - Search Results

1

Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis.

Pinheiro F, Varejão N, Esperante S, Santos J, Velázquez-Campoy A, Reverter D, Pallarès I, Ventura S. Pinheiro F, et al. Among authors: varejao n. FEBS J. 2021 Jan;288(1):310-324. doi: 10.1111/febs.15339. Epub 2020 May 11. FEBS J. 2021. PMID: 32324953 Free article.

2

Structure-based analysis of A19D, a variant of transthyretin involved in familial amyloid cardiomyopathy.

Ferreira P, Sant'Anna R, Varejão N, Lima C, Novis S, Barbosa RV, Caldeira CM, Rumjanek FD, Ventura S, Cruz MW, Foguel D. Ferreira P, et al. Among authors: varejao n. PLoS One. 2013 Dec 17;8(12):e82484. doi: 10.1371/journal.pone.0082484. eCollection 2013. PLoS One. 2013. PMID: 24358189 Free PMC article.

3

The importance of a gatekeeper residue on the aggregation of transthyretin: implications for transthyretin-related amyloidoses.

Sant'Anna R, Braga C, Varejão N, Pimenta KM, Graña-Montes R, Alves A, Cortines J, Cordeiro Y, Ventura S, Foguel D. Sant'Anna R, et al. Among authors: varejao n. J Biol Chem. 2014 Oct 10;289(41):28324-37. doi: 10.1074/jbc.M114.563981. Epub 2014 Aug 1. J Biol Chem. 2014. PMID: 25086037 Free PMC article.

4

Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation.

Sant'Anna R, Almeida MR, Varejāo N, Gallego P, Esperante S, Ferreira P, Pereira-Henriques A, Palhano FL, de Carvalho M, Foguel D, Reverter D, Saraiva MJ, Ventura S. Sant'Anna R, et al. Among authors: varejao n. Sci Rep. 2017 Mar 24;7:44709. doi: 10.1038/srep44709. Sci Rep. 2017. PMID: 28338000 Free PMC article.

5

Structural Mechanism for the Temperature-Dependent Activation of the Hyperthermophilic Pf2001 Esterase.

Varejão N, De-Andrade RA, Almeida RV, Anobom CD, Foguel D, Reverter D. Varejão N, et al. Structure. 2018 Feb 6;26(2):199-208.e3. doi: 10.1016/j.str.2017.12.004. Epub 2018 Jan 4. Structure. 2018. PMID: 29307486 Free article.

6

DNA activates the Nse2/Mms21 SUMO E3 ligase in the Smc5/6 complex.

Varejão N, Ibars E, Lascorz J, Colomina N, Torres-Rosell J, Reverter D. Varejão N, et al. EMBO J. 2018 Jun 15;37(12):e98306. doi: 10.15252/embj.201798306. Epub 2018 May 16. EMBO J. 2018. PMID: 29769404 Free PMC article.

7

Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility.

Gil-Garcia M, Bañó-Polo M, Varejão N, Jamroz M, Kuriata A, Díaz-Caballero M, Lascorz J, Morel B, Navarro S, Reverter D, Kmiecik S, Ventura S. Gil-Garcia M, et al. Among authors: varejao n. Mol Pharm. 2018 Sep 4;15(9):3846-3859. doi: 10.1021/acs.molpharmaceut.8b00341. Epub 2018 Aug 6. Mol Pharm. 2018. PMID: 30036481

8

Molecular mechanisms in SUMO conjugation.

Varejão N, Lascorz J, Li Y, Reverter D. Varejão N, et al. Biochem Soc Trans. 2020 Feb 28;48(1):123-135. doi: 10.1042/BST20190357. Biochem Soc Trans. 2020. PMID: 31872228 Review.

9

Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.

Esperante SA, Varejāo N, Pinheiro F, Sant'Anna R, Luque-Ortega JR, Alfonso C, Sora V, Papaleo E, Rivas G, Reverter D, Ventura S. Esperante SA, et al. Among authors: varejao n. J Biol Chem. 2021 Sep;297(3):101039. doi: 10.1016/j.jbc.2021.101039. Epub 2021 Jul 31. J Biol Chem. 2021. PMID: 34343569 Free PMC article.

10

Structural basis for the E3 ligase activity enhancement of yeast Nse2 by SUMO-interacting motifs.

Varejão N, Lascorz J, Codina-Fabra J, Bellí G, Borràs-Gas H, Torres-Rosell J, Reverter D. Varejão N, et al. Nat Commun. 2021 Dec 1;12(1):7013. doi: 10.1038/s41467-021-27301-9. Nat Commun. 2021. PMID: 34853311 Free PMC article.

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