Singh PK - Search Results

1

Cell free DNA from respiratory pathogens is detectable in the blood plasma of Cystic Fibrosis patients.

Barrett SLR, Holmes EA, Long DR, Shean RC, Bautista GE, Ravishankar S, Peddu V, Cookson BT, Singh PK, Greninger AL, Salipante SJ. Barrett SLR, et al. Among authors: singh pk. Sci Rep. 2020 Apr 23;10(1):6903. doi: 10.1038/s41598-020-63970-0. Sci Rep. 2020. PMID: 32327704 Free PMC article.

2

Direct sampling of cystic fibrosis lungs indicates that DNA-based analyses of upper-airway specimens can misrepresent lung microbiota.

Goddard AF, Staudinger BJ, Dowd SE, Joshi-Datar A, Wolcott RD, Aitken ML, Fligner CL, Singh PK. Goddard AF, et al. Among authors: singh pk. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13769-74. doi: 10.1073/pnas.1107435109. Epub 2012 Aug 7. Proc Natl Acad Sci U S A. 2012. PMID: 22872870 Free PMC article.

3

Regional Isolation Drives Bacterial Diversification within Cystic Fibrosis Lungs.

Jorth P, Staudinger BJ, Wu X, Hisert KB, Hayden H, Garudathri J, Harding CL, Radey MC, Rezayat A, Bautista G, Berrington WR, Goddard AF, Zheng C, Angermeyer A, Brittnacher MJ, Kitzman J, Shendure J, Fligner CL, Mittler J, Aitken ML, Manoil C, Bruce JE, Yahr TL, Singh PK. Jorth P, et al. Among authors: singh pk. Cell Host Microbe. 2015 Sep 9;18(3):307-19. doi: 10.1016/j.chom.2015.07.006. Epub 2015 Aug 20. Cell Host Microbe. 2015. PMID: 26299432 Free PMC article.

4

Evolved Aztreonam Resistance Is Multifactorial and Can Produce Hypervirulence in Pseudomonas aeruginosa.

Jorth P, McLean K, Ratjen A, Secor PR, Bautista GE, Ravishankar S, Rezayat A, Garudathri J, Harrison JJ, Harwood RA, Penewit K, Waalkes A, Singh PK, Salipante SJ. Jorth P, et al. Among authors: singh pk. mBio. 2017 Oct 31;8(5):e00517-17. doi: 10.1128/mBio.00517-17. mBio. 2017. PMID: 29089424 Free PMC article.

5

Gallium disrupts bacterial iron metabolism and has therapeutic effects in mice and humans with lung infections.

Goss CH, Kaneko Y, Khuu L, Anderson GD, Ravishankar S, Aitken ML, Lechtzin N, Zhou G, Czyz DM, McLean K, Olakanmi O, Shuman HA, Teresi M, Wilhelm E, Caldwell E, Salipante SJ, Hornick DB, Siehnel RJ, Becker L, Britigan BE, Singh PK. Goss CH, et al. Among authors: singh pk. Sci Transl Med. 2018 Sep 26;10(460):eaat7520. doi: 10.1126/scitranslmed.aat7520. Sci Transl Med. 2018. PMID: 30257953 Free PMC article. Clinical Trial.

6

Bacterial fitness in chronic wounds appears to be mediated by the capacity for high-density growth, not virulence or biofilm functions.

Morgan SJ, Lippman SI, Bautista GE, Harrison JJ, Harding CL, Gallagher LA, Cheng AC, Siehnel R, Ravishankar S, Usui ML, Olerud JE, Fleckman P, Wolcott RD, Manoil C, Singh PK. Morgan SJ, et al. Among authors: singh pk. PLoS Pathog. 2019 Mar 20;15(3):e1007511. doi: 10.1371/journal.ppat.1007511. eCollection 2019 Mar. PLoS Pathog. 2019. PMID: 30893371 Free PMC article.

7

Direct Lung Sampling Indicates That Established Pathogens Dominate Early Infections in Children with Cystic Fibrosis.

Jorth P, Ehsan Z, Rezayat A, Caldwell E, Pope C, Brewington JJ, Goss CH, Benscoter D, Clancy JP, Singh PK. Jorth P, et al. Among authors: singh pk. Cell Rep. 2019 Apr 23;27(4):1190-1204.e3. doi: 10.1016/j.celrep.2019.03.086. Cell Rep. 2019. PMID: 31018133 Free PMC article.

8

Combining Ivacaftor and Intensive Antibiotics Achieves Limited Clearance of Cystic Fibrosis Infections.

Durfey SL, Pipavath S, Li A, Vo AT, Ratjen A, Carter S, Morgan SJ, Radey MC, Grogan B, Salipante SJ, Welsh MJ, Stoltz DA, Goss CH, McKone EF, Singh PK. Durfey SL, et al. Among authors: singh pk. mBio. 2021 Dec 21;12(6):e0314821. doi: 10.1128/mbio.03148-21. Epub 2021 Dec 14. mBio. 2021. PMID: 34903059 Free PMC article. Clinical Trial.

9

A population-level strain genotyping method to study pathogen strain dynamics in human infections.

Morgan SJ, Durfey SL, Ravishankar S, Jorth P, Ni W, Skerrett DT, Aitken ML, McKone EF, Salipante SJ, Radey MC, Singh PK. Morgan SJ, et al. Among authors: singh pk. JCI Insight. 2021 Dec 22;6(24):e152472. doi: 10.1172/jci.insight.152472. JCI Insight. 2021. PMID: 34935640 Free PMC article.

10

Genome Capture Sequencing Selectively Enriches Bacterial DNA and Enables Genome-Wide Measurement of Intrastrain Genetic Diversity in Human Infections.

Hayden HS, Joshi S, Radey MC, Vo AT, Forsberg C, Morgan SJ, Waalkes A, Holmes EA, Klee SM, Emond MJ, Singh PK, Salipante SJ. Hayden HS, et al. Among authors: singh pk. mBio. 2022 Oct 26;13(5):e0142422. doi: 10.1128/mbio.01424-22. Epub 2022 Sep 19. mBio. 2022. PMID: 36121157 Free PMC article.

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