Muegge I - Search Results

1

Positional Analogue Scanning: An Effective Strategy for Multiparameter Optimization in Drug Design.

Pennington LD, Aquila BM, Choi Y, Valiulin RA, Muegge I. Pennington LD, et al. Among authors: muegge i. J Med Chem. 2020 Sep 10;63(17):8956-8976. doi: 10.1021/acs.jmedchem.9b02092. Epub 2020 Apr 24. J Med Chem. 2020. PMID: 32330036

2

Holistic drug design for multiparameter optimization in modern small molecule drug discovery.

Pennington LD, Muegge I. Pennington LD, et al. Among authors: muegge i. Bioorg Med Chem Lett. 2021 Jun 1;41:128003. doi: 10.1016/j.bmcl.2021.128003. Epub 2021 Mar 31. Bioorg Med Chem Lett. 2021. PMID: 33798703 Review.

3

Design and synthesis of substituted nicotinamides as inhibitors of soluble epoxide hydrolase.

Taylor SJ, Soleymanzadeh F, Eldrup AB, Farrow NA, Muegge I, Kukulka A, Kabcenell AK, De Lombaert S. Taylor SJ, et al. Among authors: muegge i. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5864-8. doi: 10.1016/j.bmcl.2009.08.074. Epub 2009 Aug 26. Bioorg Med Chem Lett. 2009. PMID: 19758802

4

Simple selection criteria for drug-like chemical matter.

Muegge I, Heald SL, Brittelli D. Muegge I, et al. J Med Chem. 2001 Jun 7;44(12):1841-6. doi: 10.1021/jm015507e. J Med Chem. 2001. PMID: 11384230

5

Virtual screening for kinase targets.

Muegge I, Enyedy IJ. Muegge I, et al. Curr Med Chem. 2004 Mar;11(6):693-707. doi: 10.2174/0929867043455684. Curr Med Chem. 2004. PMID: 15032724 Review.

6

Structure-based optimization of arylamides as inhibitors of soluble epoxide hydrolase.

Eldrup AB, Soleymanzadeh F, Taylor SJ, Muegge I, Farrow NA, Joseph D, McKellop K, Man CC, Kukulka A, De Lombaert S. Eldrup AB, et al. Among authors: muegge i. J Med Chem. 2009 Oct 8;52(19):5880-95. doi: 10.1021/jm9005302. J Med Chem. 2009. PMID: 19746975

7

Fragment-based discovery of indole inhibitors of matrix metalloproteinase-13.

Taylor SJ, Abeywardane A, Liang S, Muegge I, Padyana AK, Xiong Z, Hill-Drzewi M, Farmer B, Li X, Collins B, Li JX, Heim-Riether A, Proudfoot J, Zhang Q, Goldberg D, Zuvela-Jelaska L, Zaher H, Li J, Farrow NA. Taylor SJ, et al. Among authors: muegge i. J Med Chem. 2011 Dec 8;54(23):8174-87. doi: 10.1021/jm201129m. Epub 2011 Nov 9. J Med Chem. 2011. PMID: 22017539

8

Automatically updating predictive modeling workflows support decision-making in drug design.

Muegge I, Bentzien J, Mukherjee P, Hughes RO. Muegge I, et al. Future Med Chem. 2016 Sep;8(14):1779-96. doi: 10.4155/fmc-2016-0070. Epub 2016 Sep 1. Future Med Chem. 2016. PMID: 27584594

9

Selection criteria for drug-like compounds.

Muegge I. Muegge I. Med Res Rev. 2003 May;23(3):302-21. doi: 10.1002/med.10041. Med Res Rev. 2003. PMID: 12647312 Review.

10

Deconstruction of sulfonamide inhibitors of the urotensin receptor (UT) and design and synthesis of benzylamine and benzylsulfone antagonists.

Taylor SJ, Soleymanzadeh F, Muegge I, Akiba I, Taki N, Ueda S, Mainolfi E, Eldrup AB. Taylor SJ, et al. Among authors: muegge i. Bioorg Med Chem Lett. 2013 Apr 1;23(7):2177-80. doi: 10.1016/j.bmcl.2013.01.105. Epub 2013 Feb 4. Bioorg Med Chem Lett. 2013. PMID: 23453841

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