Waaler J - Search Results

1

Tankyrase inhibition sensitizes melanoma to PD-1 immune checkpoint blockade in syngeneic mouse models.

Waaler J, Mygland L, Tveita A, Strand MF, Solberg NT, Olsen PA, Aizenshtadt A, Fauskanger M, Lund K, Brinch SA, Lycke M, Dybing E, Nygaard V, Bøe SL, Heintz KM, Hovig E, Hammarström C, Corthay A, Krauss S. Waaler J, et al. Commun Biol. 2020 Apr 24;3(1):196. doi: 10.1038/s42003-020-0916-2. Commun Biol. 2020. PMID: 32332858 Free PMC article.

2

Novel synthetic antagonists of canonical Wnt signaling inhibit colorectal cancer cell growth.

Waaler J, Machon O, von Kries JP, Wilson SR, Lundenes E, Wedlich D, Gradl D, Paulsen JE, Machonova O, Dembinski JL, Dinh H, Krauss S. Waaler J, et al. Cancer Res. 2011 Jan 1;71(1):197-205. doi: 10.1158/0008-5472.CAN-10-1282. Cancer Res. 2011. PMID: 21199802

3

A novel tankyrase inhibitor decreases canonical Wnt signaling in colon carcinoma cells and reduces tumor growth in conditional APC mutant mice.

Waaler J, Machon O, Tumova L, Dinh H, Korinek V, Wilson SR, Paulsen JE, Pedersen NM, Eide TJ, Machonova O, Gradl D, Voronkov A, von Kries JP, Krauss S. Waaler J, et al. Cancer Res. 2012 Jun 1;72(11):2822-32. doi: 10.1158/0008-5472.CAN-11-3336. Epub 2012 Mar 22. Cancer Res. 2012. PMID: 22440753

4

Structural basis and SAR for G007-LK, a lead stage 1,2,4-triazole based specific tankyrase 1/2 inhibitor.

Voronkov A, Holsworth DD, Waaler J, Wilson SR, Ekblad B, Perdreau-Dahl H, Dinh H, Drewes G, Hopf C, Morth JP, Krauss S. Voronkov A, et al. Among authors: waaler j. J Med Chem. 2013 Apr 11;56(7):3012-23. doi: 10.1021/jm4000566. Epub 2013 Mar 29. J Med Chem. 2013. PMID: 23473363

5

A novel tankyrase small-molecule inhibitor suppresses APC mutation-driven colorectal tumor growth.

Lau T, Chan E, Callow M, Waaler J, Boggs J, Blake RA, Magnuson S, Sambrone A, Schutten M, Firestein R, Machon O, Korinek V, Choo E, Diaz D, Merchant M, Polakis P, Holsworth DD, Krauss S, Costa M. Lau T, et al. Among authors: waaler j. Cancer Res. 2013 May 15;73(10):3132-44. doi: 10.1158/0008-5472.CAN-12-4562. Epub 2013 Mar 28. Cancer Res. 2013. PMID: 23539443

6

The tankyrase-specific inhibitor JW74 affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines.

Stratford EW, Daffinrud J, Munthe E, Castro R, Waaler J, Krauss S, Myklebost O. Stratford EW, et al. Among authors: waaler j. Cancer Med. 2014 Feb;3(1):36-46. doi: 10.1002/cam4.170. Epub 2013 Dec 17. Cancer Med. 2014. PMID: 24403055 Free PMC article.

7

Structure, Dynamics, and Functionality of Tankyrase Inhibitor-Induced Degradasomes.

Thorvaldsen TE, Pedersen NM, Wenzel EM, Schultz SW, Brech A, Liestøl K, Waaler J, Krauss S, Stenmark H. Thorvaldsen TE, et al. Among authors: waaler j. Mol Cancer Res. 2015 Nov;13(11):1487-501. doi: 10.1158/1541-7786.MCR-15-0125. Epub 2015 Jun 29. Mol Cancer Res. 2015. PMID: 26124443

8

The PARsylation activity of tankyrase in adipose tissue modulates systemic glucose metabolism in mice.

Zhong L, Ding Y, Bandyopadhyay G, Waaler J, Börgeson E, Smith S, Zhang M, Phillips SA, Mahooti S, Mahata SK, Shao J, Krauss S, Chi NW. Zhong L, et al. Among authors: waaler j. Diabetologia. 2016 Mar;59(3):582-91. doi: 10.1007/s00125-015-3815-1. Epub 2015 Dec 2. Diabetologia. 2016. PMID: 26631215

9

Development and structural analysis of adenosine site binding tankyrase inhibitors.

Haikarainen T, Waaler J, Ignatev A, Nkizinkiko Y, Venkannagari H, Obaji E, Krauss S, Lehtiö L. Haikarainen T, et al. Among authors: waaler j. Bioorg Med Chem Lett. 2016 Jan 15;26(2):328-333. doi: 10.1016/j.bmcl.2015.12.018. Epub 2015 Dec 8. Bioorg Med Chem Lett. 2016. PMID: 26706174 Free article.

10

Discovery of a Novel Series of Tankyrase Inhibitors by a Hybridization Approach.

Anumala UR, Waaler J, Nkizinkiko Y, Ignatev A, Lazarow K, Lindemann P, Olsen PA, Murthy S, Obaji E, Majouga AG, Leonov S, von Kries JP, Lehtiö L, Krauss S, Nazaré M. Anumala UR, et al. Among authors: waaler j. J Med Chem. 2017 Dec 28;60(24):10013-10025. doi: 10.1021/acs.jmedchem.7b00883. Epub 2017 Dec 8. J Med Chem. 2017. PMID: 29155568

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