Rock BM - Search Results

1

Emerging siRNA Design Principles and Consequences for Biotransformation and Disposition in Drug Development.

Humphreys SC, Thayer MB, Campbell J, Chen WLK, Adams D, Lade JM, Rock BM. Humphreys SC, et al. Among authors: rock bm. J Med Chem. 2020 Jun 25;63(12):6407-6422. doi: 10.1021/acs.jmedchem.9b01839. Epub 2020 May 26. J Med Chem. 2020. PMID: 32352779

2

Quantification of siRNA-Antibody Conjugates in Biological Matrices by Triplex-Forming Oligonucleotide ELISA.

Humphreys SC, Thayer MB, Campuzano IDG, Netirojjanakul C, Rock BM. Humphreys SC, et al. Among authors: rock bm. Nucleic Acid Ther. 2019 Jun;29(3):161-166. doi: 10.1089/nat.2018.0770. Epub 2019 Mar 12. Nucleic Acid Ther. 2019. PMID: 30801231

3

Application of Locked Nucleic Acid Oligonucleotides for siRNA Preclinical Bioanalytics.

Thayer MB, Lade JM, Doherty D, Xie F, Basiri B, Barnaby OS, Bala NS, Rock BM. Thayer MB, et al. Among authors: rock bm. Sci Rep. 2019 Mar 5;9(1):3566. doi: 10.1038/s41598-019-40187-4. Sci Rep. 2019. PMID: 30837588 Free PMC article.

4

Plasma and Liver Protein Binding of N-Acetylgalactosamine-Conjugated Small Interfering RNA.

Humphreys SC, Thayer MB, Lade JM, Wu B, Sham K, Basiri B, Hao Y, Huang X, Smith R, Rock BM. Humphreys SC, et al. Among authors: rock bm. Drug Metab Dispos. 2019 Oct;47(10):1174-1182. doi: 10.1124/dmd.119.086967. Epub 2019 May 16. Drug Metab Dispos. 2019. PMID: 31097425

5

Pharmacokinetic and Drug Metabolism Properties of Novel Therapeutic Modalities.

Rock BM, Foti RS. Rock BM, et al. Drug Metab Dispos. 2019 Oct;47(10):1097-1099. doi: 10.1124/dmd.119.088708. Epub 2019 Aug 9. Drug Metab Dispos. 2019. PMID: 31399505

6

POE Immunoassay: Plate-based oligonucleotide electro-chemiluminescent immunoassay for the quantification of nucleic acids in biological matrices.

Thayer MB, Humphreys SC, Chung KS, Lade JM, Cook KD, Rock BM. Thayer MB, et al. Among authors: rock bm. Sci Rep. 2020 Jun 26;10(1):10425. doi: 10.1038/s41598-020-66829-6. Sci Rep. 2020. PMID: 32591626 Free PMC article.

7

Introducing an In Vitro Liver Stability Assay Capable of Predicting the In Vivo Pharmacodynamic Efficacy of siRNAs for IVIVC.

Basiri B, Xie F, Wu B, Humphreys SC, Lade JM, Thayer MB, Yamaguchi P, Florio M, Rock BM. Basiri B, et al. Among authors: rock bm. Mol Ther Nucleic Acids. 2020 Sep 4;21:725-736. doi: 10.1016/j.omtn.2020.07.012. Epub 2020 Jul 10. Mol Ther Nucleic Acids. 2020. PMID: 32771924 Free PMC article.

8

Universal Automated Immunoaffinity Purification-CE-MS Platform for Accelerating Next Generation Biologic Design.

Han M, Wang Y, Cook K, Bala N, Soto M, Rock DA, Pearson JT, Rock BM. Han M, et al. Among authors: rock bm. Anal Chem. 2021 Apr 6;93(13):5562-5569. doi: 10.1021/acs.analchem.1c00149. Epub 2021 Mar 25. Anal Chem. 2021. PMID: 33764735

9

Case Study 12: Roadmap to Quantifying Ago2-Mediated siRNA Metabolic Activation Kinetics.

Humphreys SC, Basiri B, Abbasi A, Rock BM. Humphreys SC, et al. Among authors: rock bm. Methods Mol Biol. 2021;2342:825-841. doi: 10.1007/978-1-0716-1554-6_31. Methods Mol Biol. 2021. PMID: 34272719

10

Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs.

Bai N, Riching KM, Makaju A, Wu H, Acker TM, Ou SC, Zhang Y, Shen X, Bulloch DN, Rui H, Gibson BW, Daniels DL, Urh M, Rock BM, Humphreys SC. Bai N, et al. Among authors: rock bm. J Biol Chem. 2022 Apr;298(4):101653. doi: 10.1016/j.jbc.2022.101653. Epub 2022 Jan 29. J Biol Chem. 2022. PMID: 35101445 Free PMC article.

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