Competitive and Synergistic Interactions between Polymer Micelles, Drugs, and Cyclodextrins: The Importance of Drug Solubilization Locus.
Valero M, Castiglione F, Mele A, da Silva MA, Grillo I, González-Gaitano G, Dreiss CA.
Valero M, et al.
Langmuir. 2016 Dec 13;32(49):13174-13186. doi: 10.1021/acs.langmuir.6b03367. Epub 2016 Dec 1.
Langmuir. 2016.
PMID: 27951706
Four drugs were studied at physiological temperature: lidocaine (LD), pentobarbital sodium salt (PB), sodium naproxen (NP), and sodium salicylate (SAL); higher temperatures shift the equilibrium toward higher drug partitioning and lower drug/CD binding compared to 25 C ( Valer …
Four drugs were studied at physiological temperature: lidocaine (LD), pentobarbital sodium salt (PB), sodium naproxen (NP), and sodium salic …