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Quantitative live imaging of Venus::BMAL1 in a mouse model reveals complex dynamics of the master circadian clock regulator.
Yang N, Smyllie NJ, Morris H, Gonçalves CF, Dudek M, Pathiranage DRJ, Chesham JE, Adamson A, Spiller DG, Zindy E, Bagnall J, Humphreys N, Hoyland J, Loudon ASI, Hastings MH, Meng QJ. Yang N, et al. Among authors: dudek m. PLoS Genet. 2020 Apr 30;16(4):e1008729. doi: 10.1371/journal.pgen.1008729. eCollection 2020 Apr. PLoS Genet. 2020. PMID: 32352975 Free PMC article.
Catabolic cytokines disrupt the circadian clock and the expression of clock-controlled genes in cartilage via an NFкB-dependent pathway.
Guo B, Yang N, Borysiewicz E, Dudek M, Williams JL, Li J, Maywood ES, Adamson A, Hastings MH, Bateman JF, White MR, Boot-Handford RP, Meng QJ. Guo B, et al. Among authors: dudek m. Osteoarthritis Cartilage. 2015 Nov;23(11):1981-8. doi: 10.1016/j.joca.2015.02.020. Osteoarthritis Cartilage. 2015. PMID: 26521744 Free PMC article.
The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity.
Dudek M, Gossan N, Yang N, Im HJ, Ruckshanthi JP, Yoshitane H, Li X, Jin D, Wang P, Boudiffa M, Bellantuono I, Fukada Y, Boot-Handford RP, Meng QJ. Dudek M, et al. J Clin Invest. 2016 Jan;126(1):365-76. doi: 10.1172/JCI82755. Epub 2015 Dec 14. J Clin Invest. 2016. PMID: 26657859 Free PMC article.
Circadian time series proteomics reveals daily dynamics in cartilage physiology.
Dudek M, Angelucci C, Pathiranage D, Wang P, Mallikarjun V, Lawless C, Swift J, Kadler KE, Boot-Handford RP, Hoyland JA, Lamande SR, Bateman JF, Meng QJ. Dudek M, et al. Osteoarthritis Cartilage. 2021 May;29(5):739-749. doi: 10.1016/j.joca.2021.02.008. Epub 2021 Feb 19. Osteoarthritis Cartilage. 2021. PMID: 33610821 Free PMC article.
Restoring the dampened expression of the core clock molecule BMAL1 protects against compression-induced intervertebral disc degeneration.
Wang D, Peng P, Dudek M, Hu X, Xu X, Shang Q, Wang D, Jia H, Wang H, Gao B, Zheng C, Mao J, Gao C, He X, Cheng P, Wang H, Zheng J, Hoyland JA, Meng QJ, Luo Z, Yang L. Wang D, et al. Among authors: dudek m. Bone Res. 2022 Feb 25;10(1):20. doi: 10.1038/s41413-022-00187-z. Bone Res. 2022. PMID: 35217644 Free PMC article.
422 results