Freund EC - Search Results

1

Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9.

Freund EC, Lock JY, Oh J, Maculins T, Delamarre L, Bohlen CJ, Haley B, Murthy A. Freund EC, et al. J Exp Med. 2020 Jul 6;217(7):e20191692. doi: 10.1084/jem.20191692. J Exp Med. 2020. PMID: 32357367 Free PMC article.

2

Integration of innate immune signalling by caspase-8 cleavage of N4BP1.

Gitlin AD, Heger K, Schubert AF, Reja R, Yan D, Pham VC, Suto E, Zhang J, Kwon YC, Freund EC, Kang J, Pham A, Caothien R, Bacarro N, Hinkle T, Xu M, McKenzie BS, Haley B, Lee WP, Lill JR, Roose-Girma M, Dohse M, Webster JD, Newton K, Dixit VM. Gitlin AD, et al. Among authors: freund ec. Nature. 2020 Nov;587(7833):275-280. doi: 10.1038/s41586-020-2796-5. Epub 2020 Sep 24. Nature. 2020. PMID: 32971525

3

IL-1 and IL-1ra are key regulators of the inflammatory response to RNA vaccines.

Tahtinen S, Tong AJ, Himmels P, Oh J, Paler-Martinez A, Kim L, Wichner S, Oei Y, McCarron MJ, Freund EC, Amir ZA, de la Cruz CC, Haley B, Blanchette C, Schartner JM, Ye W, Yadav M, Sahin U, Delamarre L, Mellman I. Tahtinen S, et al. Among authors: freund ec. Nat Immunol. 2022 Apr;23(4):532-542. doi: 10.1038/s41590-022-01160-y. Epub 2022 Mar 24. Nat Immunol. 2022. PMID: 35332327

4

Optimized Nonviral Gene Disruption in Primary Murine and Human Myeloid Cells.

Freund EC, Haag SM, Haley B, Murthy A. Freund EC, et al. Methods Mol Biol. 2023;2618:201-217. doi: 10.1007/978-1-0716-2938-3_15. Methods Mol Biol. 2023. PMID: 36905519

5

Nucleotide modifications enable rational design of TLR7-selective ligands by blocking RNase cleavage.

Tong AJ, Leylek R, Herzner AM, Rigas D, Wichner S, Blanchette C, Tahtinen S, Kemball CC, Mellman I, Haley B, Freund EC, Delamarre L. Tong AJ, et al. Among authors: freund ec. J Exp Med. 2024 Feb 5;221(2):e20230341. doi: 10.1084/jem.20230341. Epub 2023 Dec 14. J Exp Med. 2024. PMID: 38095631 Free PMC article.

6

Systematic perturbation screens identify regulators of inflammatory macrophage states and a role for TNF mRNA m6A modification.

Haag SM, Xie S, Eidenschenk C, Fortin JP, Callow M, Costa M, Lun A, Cox C, Wu SZ, Pradhan RN, Lock J, Kuhn JA, Holokai L, Thai M, Freund E, Nissenbaum A, Keir M, Bohlen CJ, Martin S, Geiger-Schuller K, Hejase HA, Yaspan BL, Melo Carlos S, Turley SJ, Murthy A. Haag SM, et al. Nat Genet. 2024 Nov;56(11):2493-2505. doi: 10.1038/s41588-024-01962-w. Epub 2024 Oct 23. Nat Genet. 2024. PMID: 39443811

7

Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons.

Sapiro AL, Freund EC, Restrepo L, Qiao HH, Bhate A, Li Q, Ni JQ, Mosca TJ, Li JB. Sapiro AL, et al. Among authors: freund ec. Cell Rep. 2020 May 19;31(7):107654. doi: 10.1016/j.celrep.2020.107654. Cell Rep. 2020. PMID: 32433963 Free PMC article.

8

Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing.

Freund EC, Sapiro AL, Li Q, Linder S, Moresco JJ, Yates JR 3rd, Li JB. Freund EC, et al. Cell Rep. 2020 May 19;31(7):107656. doi: 10.1016/j.celrep.2020.107656. Cell Rep. 2020. PMID: 32433965 Free PMC article.

9

Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines.

Hill TK, Davis AL, Wheeler FB, Kelkar SS, Freund EC, Lowther WT, Kridel SJ, Mohs AM. Hill TK, et al. Among authors: freund ec. Mol Pharm. 2016 Mar 7;13(3):720-8. doi: 10.1021/acs.molpharmaceut.5b00447. Epub 2016 Feb 8. Mol Pharm. 2016. PMID: 26824142 Free PMC article.

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