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How does spaceflight affect the acquired immune system?
Akiyama T, Horie K, Hinoi E, Hiraiwa M, Kato A, Maekawa Y, Takahashi A, Furukawa S. Akiyama T, et al. NPJ Microgravity. 2020 May 7;6:14. doi: 10.1038/s41526-020-0104-1. eCollection 2020. NPJ Microgravity. 2020. PMID: 32411817 Free PMC article. Review.
Long-term hindlimb unloading causes a preferential reduction of medullary thymic epithelial cells expressing autoimmune regulator (Aire).
Horie K, Kudo T, Yoshinaga R, Akiyama N, Sasanuma H, Kobayashi TJ, Shimbo M, Jeon H, Miyao T, Miyauchi M, Shirakawa M, Shiba D, Yoshida N, Muratani M, Takahashi S, Akiyama T. Horie K, et al. Among authors: akiyama t, akiyama n. Biochem Biophys Res Commun. 2018 Jun 27;501(3):745-750. doi: 10.1016/j.bbrc.2018.05.060. Biochem Biophys Res Commun. 2018. PMID: 29753741
Impact of spaceflight on the murine thymus and mitigation by exposure to artificial gravity during spaceflight.
Horie K, Kato T, Kudo T, Sasanuma H, Miyauchi M, Akiyama N, Miyao T, Seki T, Ishikawa T, Takakura Y, Shirakawa M, Shiba D, Hamada M, Jeon H, Yoshida N, Inoue JI, Muratani M, Takahashi S, Ohno H, Akiyama T. Horie K, et al. Among authors: akiyama t, akiyama n. Sci Rep. 2019 Dec 27;9(1):19866. doi: 10.1038/s41598-019-56432-9. Sci Rep. 2019. PMID: 31882694 Free PMC article.
Integrative analysis of scRNA-seq and scATAC-seq revealed transit-amplifying thymic epithelial cells expressing autoimmune regulator.
Miyao T, Miyauchi M, Kelly ST, Terooatea TW, Ishikawa T, Oh E, Hirai S, Horie K, Takakura Y, Ohki H, Hayama M, Maruyama Y, Seki T, Ishii H, Yabukami H, Yoshida M, Inoue A, Sakaue-Sawano A, Miyawaki A, Muratani M, Minoda A, Akiyama N, Akiyama T. Miyao T, et al. Among authors: akiyama t, akiyama n. Elife. 2022 May 17;11:e73998. doi: 10.7554/eLife.73998. Elife. 2022. PMID: 35578835 Free PMC article.
Mitochondrial protein C15ORF48 is a stress-independent inducer of autophagy that regulates oxidative stress and autoimmunity.
Takakura Y, Machida M, Terada N, Katsumi Y, Kawamura S, Horie K, Miyauchi M, Ishikawa T, Akiyama N, Seki T, Miyao T, Hayama M, Endo R, Ishii H, Maruyama Y, Hagiwara N, Kobayashi TJ, Yamaguchi N, Takano H, Akiyama T, Yamaguchi N. Takakura Y, et al. Among authors: akiyama t, akiyama n. Nat Commun. 2024 Feb 1;15(1):953. doi: 10.1038/s41467-024-45206-1. Nat Commun. 2024. PMID: 38296961 Free PMC article.
Pseudoirreversible inhibition elicits persistent efficacy of a sphingosine 1-phosphate receptor 1 antagonist.
Maruyama Y, Ohsawa Y, Suzuki T, Yamauchi Y, Ohno K, Inoue H, Yamamoto A, Hayashi M, Okuhara Y, Muramatsu W, Namiki K, Hagiwara N, Miyauchi M, Miyao T, Ishikawa T, Horie K, Hayama M, Akiyama N, Hirokawa T, Akiyama T. Maruyama Y, et al. Among authors: akiyama t, akiyama n. Nat Commun. 2024 Jul 19;15(1):5743. doi: 10.1038/s41467-024-49893-8. Nat Commun. 2024. PMID: 39030171 Free PMC article.
2,548 results