Zhang T - Search Results

1

Switch Off "Parallel Circuit": Insight of New Strategy of Simultaneously Suppressing Canonical and Noncanonical Inflammation Activation in Endotoxemic Mice.

Yan L, Liang J, Zhou Y, Huang J, Zhang T, Wang X, Yin H. Yan L, et al. Among authors: zhang t. Adv Biosyst. 2020 Jun;4(6):e2000037. doi: 10.1002/adbi.202000037. Epub 2020 May 18. Adv Biosyst. 2020. PMID: 32419296

2

Dissecting the Innate Immune Recognition of Opioid Inactive Isomer (+)-Naltrexone Derived Toll-like Receptor 4 (TLR4) Antagonists.

Zhang X, Cui F, Chen H, Zhang T, Yang K, Wang Y, Jiang Z, Rice KC, Watkins LR, Hutchinson MR, Li Y, Peng Y, Wang X. Zhang X, et al. Among authors: zhang t. J Chem Inf Model. 2018 Apr 23;58(4):816-825. doi: 10.1021/acs.jcim.7b00717. Epub 2018 Apr 11. J Chem Inf Model. 2018. PMID: 29518316 Free PMC article.

3

Stereochemistry and innate immune recognition: (+)-norbinaltorphimine targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling.

Zhang X, Peng Y, Grace PM, Metcalf MD, Kwilasz AJ, Wang Y, Zhang T, Wu S, Selfridge BR, Portoghese PS, Rice KC, Watkins LR, Hutchinson MR, Wang X. Zhang X, et al. Among authors: zhang t. FASEB J. 2019 Aug;33(8):9577-9587. doi: 10.1096/fj.201900173RRR. Epub 2019 Jun 4. FASEB J. 2019. PMID: 31162938 Free PMC article.

This is the first report showing enantioselective modulation of the innate immune TLR signaling.-Zhang, X., Peng, Y., Grace, P. M., Metcalf, M. D., Kwilasz, A. J., Wang, Y., Zhang, T., Wu, S., Selfridge, B. ...

This is the first report showing enantioselective modulation of the innate immune TLR signaling.-Zhang, X., Peng, Y., Grace, P. M., M …

4

Lovastatin inhibits Toll-like receptor 4 signaling in microglia by targeting its co-receptor myeloid differentiation protein 2 and attenuates neuropathic pain.

Peng Y, Zhang X, Zhang T, Grace PM, Li H, Wang Y, Li H, Chen H, Watkins LR, Hutchinson MR, Yin H, Wang X. Peng Y, et al. Among authors: zhang t, zhang x. Brain Behav Immun. 2019 Nov;82:432-444. doi: 10.1016/j.bbi.2019.09.013. Epub 2019 Sep 19. Brain Behav Immun. 2019. PMID: 31542403

5

Exploring Methamphetamine Nonenantioselectively Targeting Toll-like Receptor 4/Myeloid Differentiation Protein 2 by in Silico Simulations and Wet-Lab Techniques.

Zhang X, Wang Y, Wang H, Li H, Zhang T, Peng Y, Wang X. Zhang X, et al. Among authors: zhang t. J Chem Inf Model. 2020 Mar 23;60(3):1607-1613. doi: 10.1021/acs.jcim.9b01040. Epub 2020 Jan 23. J Chem Inf Model. 2020. PMID: 31935095

6

Small-Molecule Modulators of Toll-like Receptors.

Wang Y, Zhang S, Li H, Wang H, Zhang T, Hutchinson MR, Yin H, Wang X. Wang Y, et al. Among authors: zhang s, zhang t. Acc Chem Res. 2020 May 19;53(5):1046-1055. doi: 10.1021/acs.accounts.9b00631. Epub 2020 Apr 1. Acc Chem Res. 2020. PMID: 32233400 Review.

7

Artemisinin inhibits TLR4 signaling by targeting co-receptor MD2 in microglial BV-2 cells and prevents lipopolysaccharide-induced blood-brain barrier leakage in mice.

Zhang T, Zhang X, Lin C, Wu S, Wang F, Wang H, Wang Y, Peng Y, Hutchinson MR, Li H, Wang X. Zhang T, et al. Among authors: zhang x. J Neurochem. 2021 May;157(3):611-623. doi: 10.1111/jnc.15302. Epub 2021 Feb 2. J Neurochem. 2021. PMID: 33453127 Free article.

8

Nalmefene non-enantioselectively targets myeloid differentiation protein 2 and inhibits toll-like receptor 4 signaling: wet-lab techniques and in silico simulations.

Zhang X, Wang H, Wang Y, Li H, Wu S, Gao J, Zhang T, Xie J, Wang X. Zhang X, et al. Among authors: zhang t. Phys Chem Chem Phys. 2021 Jun 2;23(21):12260-12269. doi: 10.1039/d1cp00237f. Phys Chem Chem Phys. 2021. PMID: 34013938

9

Structure-activity relationship study of dihydroartemisinin C-10 hemiacetal derivatives as Toll-like receptor 4 antagonists.

Wang S, Wang H, Lin C, Zhang T, Gao J, Wu S, Wang Y, Li H, Min W, Liu C, Wang X. Wang S, et al. Among authors: zhang t. Bioorg Chem. 2021 Sep;114:105107. doi: 10.1016/j.bioorg.2021.105107. Epub 2021 Jun 21. Bioorg Chem. 2021. PMID: 34175717

10

Nicotine and its metabolite cotinine target MD2 and inhibit TLR4 signaling.

Li H, Peng Y, Lin C, Zhang X, Zhang T, Wang Y, Li Y, Wu S, Wang H, Hutchinson MR, Watkins LR, Wang X. Li H, et al. Among authors: zhang t, zhang x. Innovation (Camb). 2021 Apr 30;2(2):100111. doi: 10.1016/j.xinn.2021.100111. eCollection 2021 May 28. Innovation (Camb). 2021. PMID: 34557761 Free PMC article.

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