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Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria.
Vijay R, Guthmiller JJ, Sturtz AJ, Surette FA, Rogers KJ, Sompallae RR, Li F, Pope RL, Chan JA, de Labastida Rivera F, Andrew D, Webb L, Maury WJ, Xue HH, Engwerda CR, McCarthy JS, Boyle MJ, Butler NS. Vijay R, et al. Among authors: andrew d. Nat Immunol. 2020 Jul;21(7):790-801. doi: 10.1038/s41590-020-0678-5. Epub 2020 May 18. Nat Immunol. 2020. PMID: 32424361 Free PMC article. Clinical Trial.
Transcriptional profiling and immunophenotyping show sustained activation of blood monocytes in subpatent Plasmodium falciparum infection.
Loughland JR, Woodberry T, Field M, Andrew DW, SheelaNair A, Dooley NL, Piera KA, Amante FH, Kenangalem E, Price RN, Engwerda CR, Anstey NM, McCarthy JS, Boyle MJ, Minigo G. Loughland JR, et al. Clin Transl Immunology. 2020 Jun 18;9(6):e1144. doi: 10.1002/cti2.1144. eCollection 2020. Clin Transl Immunology. 2020. PMID: 32566226 Free PMC article.
Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection.
Chan JA, Loughland JR, de Labastida Rivera F, SheelaNair A, Andrew DW, Dooley NL, Wines BD, Amante FH, Webb L, Hogarth PM, McCarthy JS, Beeson JG, Engwerda CR, Boyle MJ. Chan JA, et al. Among authors: andrew dw. Cell Rep Med. 2020 Dec 22;1(9):100157. doi: 10.1016/j.xcrm.2020.100157. eCollection 2020 Dec 22. Cell Rep Med. 2020. PMID: 33377128 Free PMC article.
Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine.
Webster R, Sekuloski S, Odedra A, Woolley S, Jennings H, Amante F, Trenholme KR, Healer J, Cowman AF, Eriksson EM, Sathe P, Penington J, Blanch AJ, Dixon MWA, Tilley L, Duffy MF, Craig A, Storm J, Chan JA, Evans K, Papenfuss AT, Schofield L, Griffin P, Barber BE, Andrew D, Boyle MJ, de Labastida Rivera F, Engwerda C, McCarthy JS. Webster R, et al. Among authors: andrew d. BMC Med. 2021 Nov 22;19(1):293. doi: 10.1186/s12916-021-02150-x. BMC Med. 2021. PMID: 34802442 Free PMC article. Clinical Trial.
Adults with Plasmodium falciparum malaria have higher magnitude and quality of circulating T-follicular helper cells compared to children.
Oyong DA, Loughland JR, Soon MSF, Chan JA, Andrew D, Wines BD, Hogarth PM, Olver SD, Collinge AD, Varelias A, Beeson JG, Kenangalem E, Price RN, Anstey NM, Minigo G, Boyle MJ. Oyong DA, et al. Among authors: andrew d. EBioMedicine. 2022 Jan;75:103784. doi: 10.1016/j.ebiom.2021.103784. Epub 2021 Dec 27. EBioMedicine. 2022. PMID: 34968760 Free PMC article.
Automated detection and staging of malaria parasites from cytological smears using convolutional neural networks.
Davidson MS, Andradi-Brown C, Yahiya S, Chmielewski J, O'Donnell AJ, Gurung P, Jeninga MD, Prommana P, Andrew DW, Petter M, Uthaipibull C, Boyle MJ, Ashdown GW, Dvorin JD, Reece SE, Wilson DW, Cunningham KA, Ando DM, Dimon M, Baum J. Davidson MS, et al. Among authors: andrew dw. Biol Imaging. 2021 Aug 2;1:e2. doi: 10.1017/S2633903X21000015. eCollection 2021. Biol Imaging. 2021. PMID: 35036920 Free PMC article.
Age-dependent changes in circulating Tfh cells influence development of functional malaria antibodies in children.
Chan JA, Loughland JR, de la Parte L, Okano S, Ssewanyana I, Nalubega M, Nankya F, Musinguzi K, Rek J, Arinaitwe E, Tipping P, Bourke P, Andrew D, Dooley N, SheelaNair A, Wines BD, Hogarth PM, Beeson JG, Greenhouse B, Dorsey G, Kamya M, Hartel G, Minigo G, Feeney M, Jagannathan P, Boyle MJ. Chan JA, et al. Among authors: andrew d. Nat Commun. 2022 Jul 18;13(1):4159. doi: 10.1038/s41467-022-31880-6. Nat Commun. 2022. PMID: 35851033 Free PMC article.
Malaria-driven expansion of adaptive-like functional CD56-negative NK cells correlates with clinical immunity to malaria.
Ty M, Sun S, Callaway PC, Rek J, Press KD, van der Ploeg K, Nideffer J, Hu Z, Klemm S, Greenleaf W, Donato M, Tukwasibwe S, Arinaitwe E, Nankya F, Musinguzi K, Andrew D, de la Parte L, Mori DM, Lewis SN, Takahashi S, Rodriguez-Barraquer I, Greenhouse B, Blish C, Utz PJ, Khatri P, Dorsey G, Kamya M, Boyle M, Feeney M, Ssewanyana I, Jagannathan P. Ty M, et al. Among authors: andrew d. Sci Transl Med. 2023 Jan 25;15(680):eadd9012. doi: 10.1126/scitranslmed.add9012. Epub 2023 Jan 25. Sci Transl Med. 2023. PMID: 36696483 Free PMC article.
STING activation promotes autologous type I interferon-dependent development of type 1 regulatory T cells during malaria.
Wang Y, De Labastida Rivera F, Edwards CL, Frame TC, Engel JA, Bukali L, Na J, Ng SS, Corvino D, Montes de Oca M, Bunn PT, Soon MS, Andrew D, Loughland JR, Zhang J, Amante FH, Barber BE, McCarthy JS, Lopez JA, Boyle MJ, Engwerda CR. Wang Y, et al. Among authors: andrew d. J Clin Invest. 2023 Oct 2;133(19):e169417. doi: 10.1172/JCI169417. J Clin Invest. 2023. PMID: 37781920 Free PMC article.
345 results