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Infection-induced plasmablasts are a nutrient sink that impairs humoral immunity to malaria.
Vijay R, Guthmiller JJ, Sturtz AJ, Surette FA, Rogers KJ, Sompallae RR, Li F, Pope RL, Chan JA, de Labastida Rivera F, Andrew D, Webb L, Maury WJ, Xue HH, Engwerda CR, McCarthy JS, Boyle MJ, Butler NS. Vijay R, et al. Among authors: webb l. Nat Immunol. 2020 Jul;21(7):790-801. doi: 10.1038/s41590-020-0678-5. Epub 2020 May 18. Nat Immunol. 2020. PMID: 32424361 Free PMC article. Clinical Trial.
Safety and parasite clearance of artemisinin-resistant Plasmodium falciparum infection: A pilot and a randomised volunteer infection study in Australia.
Watts RE, Odedra A, Marquart L, Webb L, Abd-Rahman AN, Cascales L, Chalon S, Rebelo M, Pava Z, Collins KA, Pasay C, Chen N, Peatey CL, Möhrle JJ, McCarthy JS. Watts RE, et al. Among authors: webb l. PLoS Med. 2020 Aug 21;17(8):e1003203. doi: 10.1371/journal.pmed.1003203. eCollection 2020 Aug. PLoS Med. 2020. PMID: 32822347 Free PMC article. Clinical Trial.
Th2-like T Follicular Helper Cells Promote Functional Antibody Production during Plasmodium falciparum Infection.
Chan JA, Loughland JR, de Labastida Rivera F, SheelaNair A, Andrew DW, Dooley NL, Wines BD, Amante FH, Webb L, Hogarth PM, McCarthy JS, Beeson JG, Engwerda CR, Boyle MJ. Chan JA, et al. Among authors: webb l. Cell Rep Med. 2020 Dec 22;1(9):100157. doi: 10.1016/j.xcrm.2020.100157. eCollection 2020 Dec 22. Cell Rep Med. 2020. PMID: 33377128 Free PMC article.
Safety, pharmacokinetics, and antimalarial activity of the novel plasmodium eukaryotic translation elongation factor 2 inhibitor M5717: a first-in-human, randomised, placebo-controlled, double-blind, single ascending dose study and volunteer infection study.
McCarthy JS, Yalkinoglu Ö, Odedra A, Webster R, Oeuvray C, Tappert A, Bezuidenhout D, Giddins MJ, Dhingra SK, Fidock DA, Marquart L, Webb L, Yin X, Khandelwal A, Bagchus WM. McCarthy JS, et al. Among authors: webb l. Lancet Infect Dis. 2021 Dec;21(12):1713-1724. doi: 10.1016/S1473-3099(21)00252-8. Epub 2021 Oct 26. Lancet Infect Dis. 2021. PMID: 34715032 Free PMC article. Clinical Trial.
Characterizing the pharmacological interaction of the antimalarial combination artefenomel-piperaquine in healthy volunteers with induced blood-stage Plasmodium falciparum to predict efficacy in patients with malaria.
Abd-Rahman AN, Kaschek D, Kümmel A, Webster R, Potter AJ, Odedra A, Woolley SD, Llewellyn S, Webb L, Marquart L, Chalon S, Gaaloul ME, McCarthy JS, Möhrle JJ, Barber BE. Abd-Rahman AN, et al. Among authors: webb l. BMC Med. 2024 Nov 28;22(1):563. doi: 10.1186/s12916-024-03787-0. BMC Med. 2024. PMID: 39609822 Free PMC article. Clinical Trial.
741 results