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Discovery of Highly Selective Inhibitors of Calmodulin-Dependent Kinases That Restore Insulin Sensitivity in the Diet-Induced Obesity in Vivo Mouse Model.
Fromont C, Atzori A, Kaur D, Hashmi L, Greco G, Cabanillas A, Nguyen HV, Jones DH, Garzón M, Varela A, Stevenson B, Iacobini GP, Lenoir M, Rajesh S, Box C, Kumar J, Grant P, Novitskaya V, Morgan J, Sorrell FJ, Redondo C, Kramer A, Harris CJ, Leighton B, Vickers SP, Cheetham SC, Kenyon C, Grabowska AM, Overduin M, Berditchevski F, Weston CJ, Knapp S, Fischer PM, Butterworth S. Fromont C, et al. Among authors: jones dh. J Med Chem. 2020 Jul 9;63(13):6784-6801. doi: 10.1021/acs.jmedchem.9b01803. Epub 2020 Jun 22. J Med Chem. 2020. PMID: 32433887 Free PMC article.
Comparative Analysis of Small-Molecule LIMK1/2 Inhibitors: Chemical Synthesis, Biochemistry, and Cellular Activity.
Collins R, Lee H, Jones DH, Elkins JM, Gillespie JA, Thomas C, Baldwin AG, Jones K, Waters L, Paine M, Atack JR, Ward SE, Grubisha O, Foley DW. Collins R, et al. Among authors: jones dh, jones k. J Med Chem. 2022 Oct 27;65(20):13705-13713. doi: 10.1021/acs.jmedchem.2c00751. Epub 2022 Oct 7. J Med Chem. 2022. PMID: 36205722 Free PMC article.
Beware of N-Benzoyloxybenzamides.
Cubitt J, Davies M, Riseley R, Evans G, Gardiner SE, Kariuki BM, Ward SE, Lloyd-Evans E, Waller-Evans H, Jones DH. Cubitt J, et al. Among authors: jones dh. Molecules. 2024 Oct 31;29(21):5143. doi: 10.3390/molecules29215143. Molecules. 2024. PMID: 39519784 Free PMC article.
Central Nervous System Targeted Protein Degraders.
Thomas BAI, Lewis HL, Jones DH, Ward SE. Thomas BAI, et al. Among authors: jones dh. Biomolecules. 2023 Jul 25;13(8):1164. doi: 10.3390/biom13081164. Biomolecules. 2023. PMID: 37627229 Free PMC article. Review.
Discovery of MDI-114215: A Potent and Selective LIMK Inhibitor To Treat Fragile X Syndrome.
Baldwin AG, Foley DW, Collins R, Lee H, Jones DH, Wahab B, Waters L, Pedder J, Paine M, Feng GJ, Privitera L, Ashall-Kelly A, Thomas C, Gillespie JA, Schino L, Belelli D, Rocha C, Maussion G, Krahn AI, Durcan TM, Elkins JM, Lambert JJ, Atack JR, Ward SE. Baldwin AG, et al. Among authors: jones dh. J Med Chem. 2024 Dec 22. doi: 10.1021/acs.jmedchem.4c02694. Online ahead of print. J Med Chem. 2024. PMID: 39711116
Do new quality measures for social risk screening 'measure up'?
Potharaju K, Gottlieb LM, Pantell M, Jones DH. Potharaju K, et al. Among authors: jones dh. Curr Opin Pediatr. 2025 Feb 1;37(1):7-12. doi: 10.1097/MOP.0000000000001414. Epub 2024 Nov 2. Curr Opin Pediatr. 2025. PMID: 39509214 Review.
Neuromodulators in Men.
Minokadeh A, Matarasso SL, Jones DH. Minokadeh A, et al. Among authors: jones dh. Dermatol Surg. 2024 Sep 1;50(9S):S70-S72. doi: 10.1097/DSS.0000000000004336. Epub 2024 Jul 18. Dermatol Surg. 2024. PMID: 39196837 Review.
416 results