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214 results

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Immunotherapy with engineered bacteria by targeting the STING pathway for anti-tumor immunity.
Leventhal DS, Sokolovska A, Li N, Plescia C, Kolodziej SA, Gallant CW, Christmas R, Gao JR, James MJ, Abin-Fuentes A, Momin M, Bergeron C, Fisher A, Miller PF, West KA, Lora JM. Leventhal DS, et al. Among authors: james mj. Nat Commun. 2020 Jun 1;11(1):2739. doi: 10.1038/s41467-020-16602-0. Nat Commun. 2020. PMID: 32483165 Free PMC article.
Metabolic modulation of tumours with engineered bacteria for immunotherapy.
Canale FP, Basso C, Antonini G, Perotti M, Li N, Sokolovska A, Neumann J, James MJ, Geiger S, Jin W, Theurillat JP, West KA, Leventhal DS, Lora JM, Sallusto F, Geiger R. Canale FP, et al. Among authors: james mj. Nature. 2021 Oct;598(7882):662-666. doi: 10.1038/s41586-021-04003-2. Epub 2021 Oct 6. Nature. 2021. PMID: 34616044
An engineered bacterial therapeutic lowers urinary oxalate in preclinical models and in silico simulations of enteric hyperoxaluria.
Lubkowicz D, Horvath NG, James MJ, Cantarella P, Renaud L, Bergeron CG, Shmueli RB, Anderson C, Gao JR, Kurtz CB, Perreault M, Charbonneau MR, Isabella VM, Hava DL. Lubkowicz D, et al. Among authors: james mj. Mol Syst Biol. 2022 Mar;18(3):e10539. doi: 10.15252/msb.202110539. Mol Syst Biol. 2022. PMID: 35253995 Free PMC article.
The live biotherapeutic SYNB1353 decreases plasma methionine via directed degradation in animal models and healthy volunteers.
Perreault M, Means J, Gerson E, James M, Cotton S, Bergeron CG, Simon M, Carlin DA, Schmidt N, Moore TC, Blasbalg J, Sondheimer N, Ndugga-Kabuye K, Denney WS, Isabella VM, Lubkowicz D, Brennan A, Hava DL. Perreault M, et al. Cell Host Microbe. 2024 Mar 13;32(3):382-395.e10. doi: 10.1016/j.chom.2024.01.005. Epub 2024 Feb 2. Cell Host Microbe. 2024. PMID: 38309259 Free article.
Engineered bacteria producing aryl-hydrocarbon receptor agonists protect against ethanol-induced liver disease in mice.
Kouno T, Zeng S, Wang Y, Duan Y, Lang S, Gao B, Hartmann P, Cabré N, Llorente C, Galbert C, Emond P, Sokol H, James M, Chao CC, Gao JR, Perreault M, Hava DL, Schnabl B. Kouno T, et al. Alcohol Clin Exp Res (Hoboken). 2023 May;47(5):856-867. doi: 10.1111/acer.15048. Epub 2023 Mar 19. Alcohol Clin Exp Res (Hoboken). 2023. PMID: 36871955 Free PMC article.
Vaginal lactobacilli produce anti-inflammatory β-carboline compounds.
Glick VJ, Webber CA, Simmons LE, Martin MC, Ahmad M, Kim CH, Adams AND, Bang S, Chao MC, Howard NC, Fortune SM, Verma M, Jost M, Beura LK, James MJ, Lee SY, Mitchell CM, Clardy J, Kim KH, Gopinath S. Glick VJ, et al. Among authors: james mj. Cell Host Microbe. 2024 Nov 13;32(11):1897-1909.e7. doi: 10.1016/j.chom.2024.09.014. Epub 2024 Oct 17. Cell Host Microbe. 2024. PMID: 39423813
Quantifying Forms and Functions of Enterohepatic Bile Acid Pools in Mice.
Sudo K, Delmas-Eliason A, Soucy S, Barrack KE, Liu J, Balasubramanian A, Shu CJ, James MJ, Hegner CL, Dionne HD, Rodriguez-Palacios A, Krause HM, O'Toole GA, Karpen SJ, Dawson PA, Schultz D, Sundrud MS. Sudo K, et al. Among authors: james mj. Cell Mol Gastroenterol Hepatol. 2024;18(6):101392. doi: 10.1016/j.jcmgh.2024.101392. Epub 2024 Aug 22. Cell Mol Gastroenterol Hepatol. 2024. PMID: 39179177 Free PMC article.
Denitrative Hydroxylation of Unactivated Nitroarenes.
Duff L, Meakin H, Richardson A, Greener AJ, Smith GWA, Ocaña I, Chechik V, James MJ. Duff L, et al. Among authors: james mj. Chemistry. 2023 Mar 16;29(16):e202203807. doi: 10.1002/chem.202203807. Epub 2023 Feb 8. Chemistry. 2023. PMID: 36594445
214 results