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Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space.
Kearney SE, Zahoránszky-Kőhalmi G, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA Jr, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM. Kearney SE, et al. Among authors: eastman rt. ACS Cent Sci. 2018 Dec 26;4(12):1727-1741. doi: 10.1021/acscentsci.8b00747. Epub 2018 Dec 5. ACS Cent Sci. 2018. PMID: 30648156 Free PMC article.
An OpenData portal to share COVID-19 drug repurposing data in real time.
Brimacombe KR, Zhao T, Eastman RT, Hu X, Wang K, Backus M, Baljinnyam B, Chen CZ, Chen L, Eicher T, Ferrer M, Fu Y, Gorshkov K, Guo H, Hanson QM, Itkin Z, Kales SC, Klumpp-Thomas C, Lee EM, Michael S, Mierzwa T, Patt A, Pradhan M, Renn A, Shinn P, Shrimp JH, Viraktamath A, Wilson KM, Xu M, Zakharov AV, Zhu W, Zheng W, Simeonov A, Mathé EA, Lo DC, Hall MD, Shen M. Brimacombe KR, et al. Among authors: eastman rt. bioRxiv [Preprint]. 2020 Jun 5:2020.06.04.135046. doi: 10.1101/2020.06.04.135046. bioRxiv. 2020. PMID: 32511420 Free PMC article. Preprint.
Targeting ACE2-RBD interaction as a platform for COVID19 therapeutics: Development and drug repurposing screen of an AlphaLISA proximity assay.
Hanson QM, Wilson KM, Shen M, Itkin Z, Eastman RT, Shinn P, Hall MD. Hanson QM, et al. Among authors: eastman rt. bioRxiv [Preprint]. 2020 Jun 16:2020.06.16.154708. doi: 10.1101/2020.06.16.154708. bioRxiv. 2020. Update in: ACS Pharmacol Transl Sci. 2020 Nov 17;3(6):1352-1360. doi: 10.1021/acsptsci.0c00161 PMID: 32577632 Free PMC article. Updated. Preprint.
Discovery of Synergistic and Antagonistic Drug Combinations against SARS-CoV-2 In Vitro.
Bobrowski T, Chen L, Eastman RT, Itkin Z, Shinn P, Chen C, Guo H, Zheng W, Michael S, Simeonov A, Hall MD, Zakharov AV, Muratov EN. Bobrowski T, et al. Among authors: eastman rt. bioRxiv [Preprint]. 2020 Jun 30:2020.06.29.178889. doi: 10.1101/2020.06.29.178889. bioRxiv. 2020. Update in: Mol Ther. 2021 Feb 3;29(2):873-885. doi: 10.1016/j.ymthe.2020.12.016 PMID: 32637956 Free PMC article. Updated. Preprint.
Drug Repurposing Screen for Compounds Inhibiting the Cytopathic Effect of SARS-CoV-2.
Chen CZ, Shinn P, Itkin Z, Eastman RT, Bostwick R, Rasmussen L, Huang R, Shen M, Hu X, Wilson KM, Brooks B, Guo H, Zhao T, Klump-Thomas C, Simeonov A, Michael SG, Lo DC, Hall MD, Zheng W. Chen CZ, et al. Among authors: eastman rt. bioRxiv [Preprint]. 2020 Aug 18:2020.08.18.255877. doi: 10.1101/2020.08.18.255877. bioRxiv. 2020. Update in: Front Pharmacol. 2021 Jan 25;11:592737. doi: 10.3389/fphar.2020.592737 PMID: 32839771 Free PMC article. Updated. Preprint.
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
Abrams RPM, Yasgar A, Teramoto T, Lee MH, Dorjsuren D, Eastman RT, Malik N, Zakharov AV, Li W, Bachani M, Brimacombe K, Steiner JP, Hall MD, Balasubramanian A, Jadhav A, Padmanabhan R, Simeonov A, Nath A. Abrams RPM, et al. Among authors: eastman rt. Proc Natl Acad Sci U S A. 2020 Dec 8;117(49):31365-31375. doi: 10.1073/pnas.2005463117. Epub 2020 Nov 23. Proc Natl Acad Sci U S A. 2020. PMID: 33229545 Free PMC article.
Synergistic and Antagonistic Drug Combinations against SARS-CoV-2.
Bobrowski T, Chen L, Eastman RT, Itkin Z, Shinn P, Chen CZ, Guo H, Zheng W, Michael S, Simeonov A, Hall MD, Zakharov AV, Muratov EN. Bobrowski T, et al. Among authors: eastman rt. Mol Ther. 2021 Feb 3;29(2):873-885. doi: 10.1016/j.ymthe.2020.12.016. Epub 2020 Dec 15. Mol Ther. 2021. PMID: 33333292 Free PMC article.
70 results