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Protein fraction of Calotropis procera latex protects against 5-fluorouracil-induced oral mucositis associated with downregulation of pivotal pro-inflammatory mediators.
Freitas AP, Bitencourt FS, Brito GA, de Alencar NM, Ribeiro RA, Lima-Júnior RC, Ramos MV, Vale ML. Freitas AP, et al. Naunyn Schmiedebergs Arch Pharmacol. 2012 Oct;385(10):981-90. doi: 10.1007/s00210-012-0778-3. Epub 2012 Jul 14. Naunyn Schmiedebergs Arch Pharmacol. 2012. PMID: 22797601
Protective Effect of Cashew Gum (Anacardium occidentale L.) on 5-Fluorouracil-Induced Intestinal Mucositis.
de Miranda JAL, Barreto JEF, Martins DS, de Souza Pimentel PV, da Silva Costa DV, E Silva RR, de Souza LKM, de Lima CNC, Rocha JA, de Freitas APF, da Silva DA, Scafuri AG, de Leitão RFC, de Castro Brito GA, Medeiros JVR, Cerqueira GS. de Miranda JAL, et al. Among authors: de freitas apf. Pharmaceuticals (Basel). 2019 Apr 3;12(2):51. doi: 10.3390/ph12020051. Pharmaceuticals (Basel). 2019. PMID: 30987265 Free PMC article.
Side-Effects of Irinotecan (CPT-11), the Clinically Used Drug for Colon Cancer Therapy, Are Eliminated in Experimental Animals Treated with Latex Proteins from Calotropis procera (Apocynaceae).
de Alencar NM, da Silveira Bitencourt F, de Figueiredo IS, Luz PB, Lima-Júnior RC, Aragão KS, Magalhães PJ, de Castro Brito GA, Ribeiro RA, de Freitas AP, Ramos MV. de Alencar NM, et al. Phytother Res. 2017 Feb;31(2):312-320. doi: 10.1002/ptr.5752. Epub 2016 Dec 2. Phytother Res. 2017. PMID: 27910140