Negoro T - Search Results

1

Discovery of a Janus Kinase Inhibitor Bearing a Highly Three-Dimensional Spiro Scaffold: JTE-052 (Delgocitinib) as a New Dermatological Agent to Treat Inflammatory Skin Disorders.

Noji S, Hara Y, Miura T, Yamanaka H, Maeda K, Hori A, Yamamoto H, Obika S, Inoue M, Hase Y, Orita T, Doi S, Adachi T, Tanimoto A, Oki C, Kimoto Y, Ogawa Y, Negoro T, Hashimoto H, Shiozaki M. Noji S, et al. Among authors: negoro t. J Med Chem. 2020 Jul 9;63(13):7163-7185. doi: 10.1021/acs.jmedchem.0c00450. Epub 2020 Jun 29. J Med Chem. 2020. PMID: 32511913

2

Concise SAR Exploration Based on the "Head-to-Tail" Approach: Discovery of PI4KIIIα Inhibitors Bearing Diverse Scaffolds.

Noji S, Seki N, Maeba T, Sakai T, Watanabe E, Maeda K, Fukushima K, Noguchi T, Ogawa K, Toyonaga Y, Negoro T, Kawasaki H, Shiozaki M. Noji S, et al. Among authors: negoro t. ACS Med Chem Lett. 2016 Aug 3;7(10):919-923. doi: 10.1021/acsmedchemlett.6b00232. eCollection 2016 Oct 13. ACS Med Chem Lett. 2016. PMID: 27774129 Free PMC article.

3

Discovery of potent liver-selective stearoyl-CoA desaturase-1 (SCD1) inhibitors, thiazole-4-acetic acid derivatives, for the treatment of diabetes, hepatic steatosis, and obesity.

Iida T, Ubukata M, Mitani I, Nakagawa Y, Maeda K, Imai H, Ogoshi Y, Hotta T, Sakata S, Sano R, Morinaga H, Negoro T, Oshida S, Tanaka M, Inaba T. Iida T, et al. Among authors: negoro t. Eur J Med Chem. 2018 Oct 5;158:832-852. doi: 10.1016/j.ejmech.2018.09.003. Eur J Med Chem. 2018. PMID: 30248655

4

Lead generation and optimization of novel GPR119 agonists with a spirocyclic cyclohexane structure.

Harada K, Mizukami J, Watanabe T, Mori G, Ubukata M, Suwa K, Fukuda S, Negoro T, Sato M, Inaba T. Harada K, et al. Among authors: negoro t. Bioorg Med Chem Lett. 2019 Feb 1;29(3):373-379. doi: 10.1016/j.bmcl.2018.12.041. Epub 2018 Dec 18. Bioorg Med Chem Lett. 2019. PMID: 30587450

5

Optimization of oxadiazole derivatives with a spirocyclic cyclohexane structure as novel GPR119 agonists.

Harada K, Mizukami J, Watanabe T, Mori G, Ubukata M, Suwa K, Fukuda S, Negoro T, Sato M, Inaba T. Harada K, et al. Among authors: negoro t. Bioorg Med Chem Lett. 2019 Aug 15;29(16):2100-2106. doi: 10.1016/j.bmcl.2019.07.004. Epub 2019 Jul 3. Bioorg Med Chem Lett. 2019. PMID: 31288965

6

JTP-117968, a novel selective glucocorticoid receptor modulator, exhibits improved transrepression/transactivation dissociation.

Kurimoto T, Tamai I, Miyai A, Kosugi Y, Nakagawa T, Yamamoto Y, Deai K, Misaki S, Bessho Y, Negoro T, Yamaguchi T, Hata T, Matsushita M. Kurimoto T, et al. Among authors: negoro t. Eur J Pharmacol. 2017 May 15;803:179-186. doi: 10.1016/j.ejphar.2017.03.057. Epub 2017 Mar 31. Eur J Pharmacol. 2017. PMID: 28366807

7

Predicted values for human total clearance of a variety of typical compounds with differently humanized-liver mouse plasma data.

Nakayama K, Kamimura H, Suemizu H, Yoneda N, Nishiwaki M, Iwamoto K, Mizunaga M, Negoro T, Ito S, Yamazaki H, Nomura Y. Nakayama K, et al. Among authors: negoro t. Drug Metab Pharmacokinet. 2020 Aug;35(4):389-396. doi: 10.1016/j.dmpk.2020.05.004. Epub 2020 May 20. Drug Metab Pharmacokinet. 2020. PMID: 32690433

8

Inhibitory effect of JTP-59557, a new triazole derivative, on intestinal phosphate transport in vitro and in vivo.

Matsuo A, Negoro T, Seo T, Kitao Y, Shindo M, Segawa H, Miyamoto K. Matsuo A, et al. Among authors: negoro t. Eur J Pharmacol. 2005 Jul 4;517(1-2):111-9. doi: 10.1016/j.ejphar.2005.05.003. Eur J Pharmacol. 2005. PMID: 15961073

9

Increase in participation of vasoactive intestinal peptide in relaxation of the distal colon of Wistar rats with age.

Takeuchi T, Negoro T, Yamaji M, Yamazaki Y, Fujita A, Nishio H, Takewaki T, Takatsuji K, Hata F. Takeuchi T, et al. Among authors: negoro t. Br J Pharmacol. 2000 Nov;131(5):942-8. doi: 10.1038/sj.bjp.0703643. Br J Pharmacol. 2000. PMID: 11053215 Free PMC article.

10

Changes in mechanism of PACAP-induced relaxation in longitudinal muscle of the distal colon of Wistar rats with age.

Takeuchi T, Yamazaki Y, Negoro T, Fujinami K, Mukai K, Fujita A, Takewaki T, Hata F. Takeuchi T, et al. Among authors: negoro t. Regul Pept. 2004 Apr 15;118(1-2):1-9. doi: 10.1016/j.regpep.2003.10.033. Regul Pept. 2004. PMID: 14759550

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