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Structure and dynamics of the ASB9 CUL-RING E3 Ligase.
Lumpkin RJ, Baker RW, Leschziner AE, Komives EA. Lumpkin RJ, et al. Nat Commun. 2020 Jun 8;11(1):2866. doi: 10.1038/s41467-020-16499-9. Nat Commun. 2020. PMID: 32513959 Free PMC article.
The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases.
Lumpkin RJ, Ahmad AS, Blake R, Condon CJ, Komives EA. Lumpkin RJ, et al. Mol Cell Proteomics. 2021;20:100019. doi: 10.1074/mcp.RA120.002414. Epub 2021 Jan 6. Mol Cell Proteomics. 2021. PMID: 33268465 Free PMC article.
Template-assisted covalent modification underlies activity of covalent molecular glues.
Li YD, Ma MW, Hassan MM, Hunkeler M, Teng M, Puvar K, Rutter JC, Lumpkin RJ, Sandoval B, Jin CY, Schmoker AM, Ficarro SB, Cheong H, Metivier RJ, Wang MY, Xu S, Byun WS, Groendyke BJ, You I, Sigua LH, Tavares I, Zou C, Tsai JM, Park PMC, Yoon H, Majewski FC, Sperling HT, Marto JA, Qi J, Nowak RP, Donovan KA, Słabicki M, Gray NS, Fischer ES, Ebert BL. Li YD, et al. Among authors: lumpkin rj. Nat Chem Biol. 2024 Dec;20(12):1640-1649. doi: 10.1038/s41589-024-01668-4. Epub 2024 Jul 29. Nat Chem Biol. 2024. PMID: 39075252 Free PMC article.
Targeted Degradation of the Oncogenic Phosphatase SHP2.
Vemulapalli V, Donovan KA, Seegar TCM, Rogers JM, Bae M, Lumpkin RJ, Cao R, Henke MT, Ray SS, Fischer ES, Cuny GD, Blacklow SC. Vemulapalli V, et al. Among authors: lumpkin rj. Biochemistry. 2021 Aug 31;60(34):2593-2609. doi: 10.1021/acs.biochem.1c00377. Epub 2021 Aug 19. Biochemistry. 2021. PMID: 34411482 Free PMC article.
18 results