Agius L - Search Results

1

Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge.

Ford BE, Chachra SS, Alshawi A, Brennan A, Harnor S, Cano C, Baker DJ, Smith DM, Fairclough RJ, Agius L. Ford BE, et al. Among authors: agius l. Diabetes Obes Metab. 2020 Nov;22(11):1985-1994. doi: 10.1111/dom.14111. Epub 2020 Jul 7. Diabetes Obes Metab. 2020. PMID: 32519798

2

Opposite effects of a glucokinase activator and metformin on glucose-regulated gene expression in hepatocytes.

Al-Oanzi ZH, Fountana S, Moonira T, Tudhope SJ, Petrie JL, Alshawi A, Patman G, Arden C, Reeves HL, Agius L. Al-Oanzi ZH, et al. Among authors: agius l. Diabetes Obes Metab. 2017 Aug;19(8):1078-1087. doi: 10.1111/dom.12910. Epub 2017 Apr 10. Diabetes Obes Metab. 2017. PMID: 28206714

3

The Protective Role of the Carbohydrate Response Element Binding Protein in the Liver: The Metabolite Perspective.

Agius L, Chachra SS, Ford BE. Agius L, et al. Front Endocrinol (Lausanne). 2020 Nov 17;11:594041. doi: 10.3389/fendo.2020.594041. eCollection 2020. Front Endocrinol (Lausanne). 2020. PMID: 33281747 Free PMC article. Review.

4

Low metformin causes a more oxidized mitochondrial NADH/NAD redox state in hepatocytes and inhibits gluconeogenesis by a redox-independent mechanism.

Alshawi A, Agius L. Alshawi A, et al. Among authors: agius l. J Biol Chem. 2019 Feb 22;294(8):2839-2853. doi: 10.1074/jbc.RA118.006670. Epub 2018 Dec 27. J Biol Chem. 2019. PMID: 30591586 Free PMC article.

5

The Metformin Mechanism on Gluconeogenesis and AMPK Activation: The Metabolite Perspective.

Agius L, Ford BE, Chachra SS. Agius L, et al. Int J Mol Sci. 2020 May 3;21(9):3240. doi: 10.3390/ijms21093240. Int J Mol Sci. 2020. PMID: 32375255 Free PMC article. Review.

6

Metformin lowers glucose 6-phosphate in hepatocytes by activation of glycolysis downstream of glucose phosphorylation.

Moonira T, Chachra SS, Ford BE, Marin S, Alshawi A, Adam-Primus NS, Arden C, Al-Oanzi ZH, Foretz M, Viollet B, Cascante M, Agius L. Moonira T, et al. Among authors: agius l. J Biol Chem. 2020 Mar 6;295(10):3330-3346. doi: 10.1074/jbc.RA120.012533. Epub 2020 Jan 23. J Biol Chem. 2020. PMID: 31974165 Free PMC article.

7

Elevated glucose represses liver glucokinase and induces its regulatory protein to safeguard hepatic phosphate homeostasis.

Arden C, Petrie JL, Tudhope SJ, Al-Oanzi Z, Claydon AJ, Beynon RJ, Towle HC, Agius L. Arden C, et al. Among authors: agius l. Diabetes. 2011 Dec;60(12):3110-20. doi: 10.2337/db11-0061. Epub 2011 Oct 19. Diabetes. 2011. PMID: 22013014 Free PMC article.

8

Stimulation of hepatocyte glucose metabolism by novel small molecule glucokinase activators.

Brocklehurst KJ, Payne VA, Davies RA, Carroll D, Vertigan HL, Wightman HJ, Aiston S, Waddell ID, Leighton B, Coghlan MP, Agius L. Brocklehurst KJ, et al. Among authors: agius l. Diabetes. 2004 Mar;53(3):535-41. doi: 10.2337/diabetes.53.3.535. Diabetes. 2004. PMID: 14988235

9

Cell biology assessment of glucokinase mutations V62M and G72R in pancreatic beta-cells: evidence for cellular instability of catalytic activity.

Arden C, Trainer A, de la Iglesia N, Scougall KT, Gloyn AL, Lange AJ, Shaw JA, Matschinsky FM, Agius L. Arden C, et al. Among authors: agius l. Diabetes. 2007 Jul;56(7):1773-82. doi: 10.2337/db06-1151. Epub 2007 Mar 27. Diabetes. 2007. PMID: 17389332

10

Increased potency and efficacy of combined phosphorylase inactivation and glucokinase activation in control of hepatocyte glycogen metabolism.

Hampson LJ, Agius L. Hampson LJ, et al. Among authors: agius l. Diabetes. 2005 Mar;54(3):617-23. doi: 10.2337/diabetes.54.3.617. Diabetes. 2005. PMID: 15734835

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