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Page 1
Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif.
Perreault S, Arjmand F, Chandrasekhar J, Hao J, Keegan KS, Koditek D, Lepist EI, Matson CK, McGrath ME, Patel L, Sedillo K, Therrien J, Till NA, Tomkinson A, Treiberg J, Zherebina Y, Phillips G. Perreault S, et al. Among authors: till na. ACS Med Chem Lett. 2020 Apr 13;11(6):1236-1243. doi: 10.1021/acsmedchemlett.0c00095. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32551006 Free PMC article.
Atropisomerism by Design: Discovery of a Selective and Stable Phosphoinositide 3-Kinase (PI3K) β Inhibitor.
Chandrasekhar J, Dick R, Van Veldhuizen J, Koditek D, Lepist EI, McGrath ME, Patel L, Phillips G, Sedillo K, Somoza JR, Therrien J, Till NA, Treiberg J, Villaseñor AG, Zherebina Y, Perreault S. Chandrasekhar J, et al. Among authors: till na. J Med Chem. 2018 Aug 9;61(15):6858-6868. doi: 10.1021/acs.jmedchem.8b00797. Epub 2018 Jul 30. J Med Chem. 2018. PMID: 30015489
Decarboxylative Hydroalkylation of Alkynes.
Till NA, Smith RT, MacMillan DWC. Till NA, et al. J Am Chem Soc. 2018 May 2;140(17):5701-5705. doi: 10.1021/jacs.8b02834. Epub 2018 Apr 20. J Am Chem Soc. 2018. PMID: 29664294 Free PMC article.
The modified RNA base acp3U is an attachment site for N-glycans in glycoRNA.
Xie Y, Chai P, Till NA, Hemberger H, Lebedenko CG, Porat J, Watkins CP, Caldwell RM, George BM, Perr J, Bertozzi CR, Garcia BA, Flynn RA. Xie Y, et al. Among authors: till na. Cell. 2024 Sep 19;187(19):5228-5237.e12. doi: 10.1016/j.cell.2024.07.044. Epub 2024 Aug 21. Cell. 2024. PMID: 39173631