Tomkinson A - Search Results

1

Discovery of an Atropisomeric PI3Kβ Selective Inhibitor through Optimization of the Hinge Binding Motif.

Perreault S, Arjmand F, Chandrasekhar J, Hao J, Keegan KS, Koditek D, Lepist EI, Matson CK, McGrath ME, Patel L, Sedillo K, Therrien J, Till NA, Tomkinson A, Treiberg J, Zherebina Y, Phillips G. Perreault S, et al. Among authors: tomkinson a. ACS Med Chem Lett. 2020 Apr 13;11(6):1236-1243. doi: 10.1021/acsmedchemlett.0c00095. eCollection 2020 Jun 11. ACS Med Chem Lett. 2020. PMID: 32551006 Free PMC article.

2

Inhaled remdesivir reduces viral burden in a nonhuman primate model of SARS-CoV-2 infection.

Vermillion MS, Murakami E, Ma B, Pitts J, Tomkinson A, Rautiola D, Babusis D, Irshad H, Seigel D, Kim C, Zhao X, Niu C, Yang J, Gigliotti A, Kadrichu N, Bilello JP, Ellis S, Bannister R, Subramanian R, Smith B, Mackman RL, Lee WA, Kuehl PJ, Hartke J, Cihlar T, Porter DP. Vermillion MS, et al. Among authors: tomkinson a. Sci Transl Med. 2022 Feb 23;14(633):eabl8282. doi: 10.1126/scitranslmed.abl8282. Epub 2022 Feb 23. Sci Transl Med. 2022. PMID: 34968150 Free PMC article.

3

Inhaled vs subcutaneous effects of a dual IL-4/IL-13 antagonist in a monkey model of asthma.

Tomkinson A, Tepper J, Morton M, Bowden A, Stevens L, Harris P, Lindell D, Fitch N, Gundel R, Getz EB. Tomkinson A, et al. Allergy. 2010 Jan;65(1):69-77. doi: 10.1111/j.1398-9995.2009.02156.x. Epub 2009 Oct 1. Allergy. 2010. PMID: 19796211

4

Allergen dose dependency of the early- and late-phase cutaneous response in the cynomolgus monkey.

Tomkinson A, Morton M, Stevens L, Bowden A, Tepper J. Tomkinson A, et al. Clin Exp Allergy. 2009 Jul;39(7):1080-7. doi: 10.1111/j.1365-2222.2009.03240.x. Epub 2009 Apr 7. Clin Exp Allergy. 2009. PMID: 19400909

5

A murine IL-4 receptor antagonist that inhibits IL-4- and IL-13-induced responses prevents antigen-induced airway eosinophilia and airway hyperresponsiveness.

Tomkinson A, Duez C, Cieslewicz G, Pratt JC, Joetham A, Shanafelt MC, Gundel R, Gelfand EW. Tomkinson A, et al. J Immunol. 2001 May 1;166(9):5792-800. doi: 10.4049/jimmunol.166.9.5792. J Immunol. 2001. PMID: 11313423

6

Treatment of experimental asthma by long-term gene therapy directed against IL-4 and IL-13.

Zavorotinskaya T, Tomkinson A, Murphy JE. Zavorotinskaya T, et al. Among authors: tomkinson a. Mol Ther. 2003 Feb;7(2):155-62. doi: 10.1016/s1525-0016(02)00050-3. Mol Ther. 2003. PMID: 12597903 Free article.

7

Local treatment with IL-12 is an effective inhibitor of airway hyperresponsiveness and lung eosinophilia after airway challenge in sensitized mice.

Schwarze J, Hamelmann E, Cieslewicz G, Tomkinson A, Joetham A, Bradley K, Gelfand EW. Schwarze J, et al. Among authors: tomkinson a. J Allergy Clin Immunol. 1998 Jul;102(1):86-93. doi: 10.1016/s0091-6749(98)70058-2. J Allergy Clin Immunol. 1998. PMID: 9679851

8

Adoptive transfer of T cells induces airway hyperresponsiveness independently of airway eosinophilia but in a signal transducer and activator of transcription 6-dependent manner.

Tomkinson A, Duez C, Lahn M, Gelfand EW. Tomkinson A, et al. J Allergy Clin Immunol. 2002 May;109(5):810-6. doi: 10.1067/mai.2002.123531. J Allergy Clin Immunol. 2002. PMID: 11994705

9

Eotaxin-1-deficient mice develop airway eosinophilia and airway hyperresponsiveness.

Tomkinson A, Duez C, Cieslewicz G, Gelfand EW. Tomkinson A, et al. Int Arch Allergy Immunol. 2001 Oct;126(2):119-25. doi: 10.1159/000049502. Int Arch Allergy Immunol. 2001. PMID: 11729349

10

Migration and accumulation of eosinophils toward regional lymph nodes after airway allergen challenge.

Duez C, Dakhama A, Tomkinson A, Marquillies P, Balhorn A, Tonnel AB, Bratton DL, Gelfand EW. Duez C, et al. Among authors: tomkinson a. J Allergy Clin Immunol. 2004 Oct;114(4):820-5. doi: 10.1016/j.jaci.2004.08.011. J Allergy Clin Immunol. 2004. PMID: 15480321

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