Georgescu R - Search Results

1

Structure of the polymerase ε holoenzyme and atomic model of the leading strand replisome.

Yuan Z, Georgescu R, Schauer GD, O'Donnell ME, Li H. Yuan Z, et al. Among authors: georgescu r. Nat Commun. 2020 Jun 22;11(1):3156. doi: 10.1038/s41467-020-16910-5. Nat Commun. 2020. PMID: 32572031 Free PMC article.

2

Structure of a sliding clamp on DNA.

Georgescu RE, Kim SS, Yurieva O, Kuriyan J, Kong XP, O'Donnell M. Georgescu RE, et al. Cell. 2008 Jan 11;132(1):43-54. doi: 10.1016/j.cell.2007.11.045. Cell. 2008. PMID: 18191219 Free PMC article.

3

Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp.

Georgescu RE, Yurieva O, Kim SS, Kuriyan J, Kong XP, O'Donnell M. Georgescu RE, et al. Proc Natl Acad Sci U S A. 2008 Aug 12;105(32):11116-21. doi: 10.1073/pnas.0804754105. Epub 2008 Aug 4. Proc Natl Acad Sci U S A. 2008. PMID: 18678908 Free PMC article.

4

Single-molecule analysis reveals that the lagging strand increases replisome processivity but slows replication fork progression.

Yao NY, Georgescu RE, Finkelstein J, O'Donnell ME. Yao NY, et al. Proc Natl Acad Sci U S A. 2009 Aug 11;106(32):13236-41. doi: 10.1073/pnas.0906157106. Epub 2009 Aug 3. Proc Natl Acad Sci U S A. 2009. PMID: 19666586 Free PMC article.

5

Mechanism of polymerase collision release from sliding clamps on the lagging strand.

Georgescu RE, Kurth I, Yao NY, Stewart J, Yurieva O, O'Donnell M. Georgescu RE, et al. EMBO J. 2009 Oct 7;28(19):2981-91. doi: 10.1038/emboj.2009.233. Epub 2009 Aug 20. EMBO J. 2009. PMID: 19696739 Free PMC article.

6

Single-molecule analysis of the Escherichia coli replisome and use of clamps to bypass replication barriers.

Georgescu RE, Yao NY, O'Donnell M. Georgescu RE, et al. FEBS Lett. 2010 Jun 18;584(12):2596-605. doi: 10.1016/j.febslet.2010.04.003. Epub 2010 Apr 11. FEBS Lett. 2010. PMID: 20388515 Free PMC article. Review.

7

Single-molecule studies reveal the function of a third polymerase in the replisome.

Georgescu RE, Kurth I, O'Donnell ME. Georgescu RE, et al. Nat Struct Mol Biol. 2011 Dec 11;19(1):113-6. doi: 10.1038/nsmb.2179. Nat Struct Mol Biol. 2011. PMID: 22157955 Free PMC article.

8

A solution to release twisted DNA during chromosome replication by coupled DNA polymerases.

Kurth I, Georgescu RE, O'Donnell ME. Kurth I, et al. Nature. 2013 Apr 4;496(7443):119-22. doi: 10.1038/nature11988. Epub 2013 Mar 27. Nature. 2013. PMID: 23535600 Free PMC article.

9

Replisome mechanics: lagging strand events that influence speed and processivity.

Georgescu RE, Yao N, Indiani C, Yurieva O, O'Donnell ME. Georgescu RE, et al. Nucleic Acids Res. 2014 Jun;42(10):6497-510. doi: 10.1093/nar/gku257. Epub 2014 May 14. Nucleic Acids Res. 2014. PMID: 24829446 Free PMC article.

10

Mechanism of asymmetric polymerase assembly at the eukaryotic replication fork.

Georgescu RE, Langston L, Yao NY, Yurieva O, Zhang D, Finkelstein J, Agarwal T, O'Donnell ME. Georgescu RE, et al. Nat Struct Mol Biol. 2014 Aug;21(8):664-70. doi: 10.1038/nsmb.2851. Epub 2014 Jul 6. Nat Struct Mol Biol. 2014. PMID: 24997598 Free PMC article.

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