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Page 1
NTAL is associated with treatment outcome, cell proliferation and differentiation in acute promyelocytic leukemia.
Thomé CH, Ferreira GA, Pereira-Martins DA, Dos Santos GA, Ortiz CA, de Souza LEB, Sobral LM, Silva CLA, Scheucher PS, Gil CD, Leopoldino AM, Silveira DRA, Coelho-Silva JL, Traina F, Koury LC, Melo RAM, Bittencourt R, Pagnano K, Pasquini R, Nunes EC, Fagundes EM, Gloria ABF, Kerbauy FR, Chauffaille ML, Keating A, Tallman MS, Ribeiro RC, Dillon R, Ganser A, Löwenberg B, Valk P, Lo-Coco F, Sanz MA, Berliner N, Faça VM, Rego EM. Thomé CH, et al. Among authors: scheucher ps. Sci Rep. 2020 Jun 25;10(1):10315. doi: 10.1038/s41598-020-66223-2. Sci Rep. 2020. PMID: 32587277 Free PMC article.
The lipid raft protein NTAL participates in AKT signaling in mantle cell lymphoma.
Ferreira GA, Thomé CH, Simão AMS, Scheucher PS, Silva CLA, Chahud F, Ciancaglini P, Leopoldino AM, Rego EM, Faça VM, Dos Santos GA. Ferreira GA, et al. Among authors: scheucher ps. Leuk Lymphoma. 2019 Nov;60(11):2658-2668. doi: 10.1080/10428194.2019.1607326. Epub 2019 May 7. Leuk Lymphoma. 2019. PMID: 31060403
STMN1 is highly expressed and contributes to clonogenicity in acute promyelocytic leukemia cells.
Vicari HP, Coelho-Silva JL, Pereira-Martins DA, Lucena-Araujo AR, Lima K, Lipreri da Silva JC, Scheucher PS, Koury LC, de Melo RA, Bittencourt R, Pagnano K, Nunes E, Fagundes EM, Kerbauy F, de Figueiredo-Pontes LL, Costa-Lotufo LV, Rego EM, Traina F, Machado-Neto JA. Vicari HP, et al. Among authors: scheucher ps. Invest New Drugs. 2022 Apr;40(2):438-452. doi: 10.1007/s10637-021-01197-0. Epub 2021 Nov 27. Invest New Drugs. 2022. PMID: 34837603
Linker for activation of T-cell family member2 (LAT2) a lipid raft adaptor protein for AKT signaling, is an early mediator of alkylphospholipid anti-leukemic activity.
Thomé CH, dos Santos GA, Ferreira GA, Scheucher PS, Izumi C, Leopoldino AM, Simão AM, Ciancaglini P, de Oliveira KT, Chin A, Hanash SM, Falcão RP, Rego EM, Greene LJ, Faça VM. Thomé CH, et al. Among authors: scheucher ps. Mol Cell Proteomics. 2012 Dec;11(12):1898-912. doi: 10.1074/mcp.M112.019661. Epub 2012 Sep 22. Mol Cell Proteomics. 2012. PMID: 23001822 Free PMC article.
ΔNp73 overexpression promotes resistance to apoptosis but does not cooperate with PML/RARA in the induction of an APL-leukemic phenotype.
Lucena-Araujo AR, Coelho-Silva JL, Pereira-Martins DA, Thomé C, Scheucher PS, Lange AP, Paiva HH, Hemmelgarn BT, Morais-Sobral MC, Azevedo EA, Franca-Neto PL, Franca RF, Silva CL, Krause A, Rego EM. Lucena-Araujo AR, et al. Among authors: scheucher ps. Oncotarget. 2017 Jan 31;8(5):8475-8483. doi: 10.18632/oncotarget.14295. Oncotarget. 2017. PMID: 28035072 Free PMC article.
IGF1R/IRS1 targeting has cytotoxic activity and inhibits PI3K/AKT/mTOR and MAPK signaling in acute lymphoblastic leukemia cells.
Rodrigues Alves APN, Fernandes JC, Fenerich BA, Coelho-Silva JL, Scheucher PS, Simões BP, Rego EM, Ridley AJ, Machado-Neto JA, Traina F. Rodrigues Alves APN, et al. Among authors: scheucher ps. Cancer Lett. 2019 Aug 1;456:59-68. doi: 10.1016/j.canlet.2019.04.030. Epub 2019 Apr 28. Cancer Lett. 2019. PMID: 31042587 Free article.
The Combination of Gefitinib With ATRA and ATO Induces Myeloid Differentiation in Acute Promyelocytic Leukemia Resistant Cells.
de Almeida LY, Pereira-Martins DA, Weinhäuser I, Ortiz C, Cândido LA, Lange AP, De Abreu NF, Mendonza SES, de Deus Wagatsuma VM, Do Nascimento MC, Paiva HH, Alves-Paiva RM, Bonaldo CCOM, Nascimento DC, Alves-Filho JC, Scheucher PS, Lima ASG, Schuringa JJ, Ammantuna E, Ottone T, Noguera NI, Araujo CL, Rego EM. de Almeida LY, et al. Among authors: scheucher ps. Front Oncol. 2021 Sep 28;11:686445. doi: 10.3389/fonc.2021.686445. eCollection 2021. Front Oncol. 2021. PMID: 34650910 Free PMC article.
Paclitaxel induces Stathmin 1 phosphorylation, microtubule stability and apoptosis in acute lymphoblastic leukemia cells.
Machado-Neto JA, Rodrigues Alves APN, Fernandes JC, Coelho-Silva JL, Scopim-Ribeiro R, Fenerich BA, da Silva FB, Scheucher PS, Simões BP, Rego EM, Traina F. Machado-Neto JA, et al. Among authors: scheucher ps. Heliyon. 2017 Sep 28;3(9):e00405. doi: 10.1016/j.heliyon.2017.e00405. eCollection 2017 Sep. Heliyon. 2017. PMID: 29034341 Free PMC article.
28 results