The p.P888L SAP97 polymorphism increases the transient outward current (Ito,f) and abbreviates the action potential duration and the QT interval.
Tinaquero D, Crespo-García T, Utrilla RG, Nieto-Marín P, González-Guerra A, Rubio-Alarcón M, Cámara-Checa A, Dago M, Matamoros M, Pérez-Hernández M, Tamargo M, Cebrián J, Jalife J, Tamargo J, Bernal JA, Caballero R, Delpón E; ITACA Investigators.
Tinaquero D, et al. Among authors: delpon e.
Sci Rep. 2020 Jul 1;10(1):10707. doi: 10.1038/s41598-020-67109-z.
Sci Rep. 2020.
PMID: 32612162
Free PMC article.