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A second generation leishmanization vaccine with a markerless attenuated Leishmania major strain using CRISPR gene editing.
Zhang WW, Karmakar S, Gannavaram S, Dey R, Lypaczewski P, Ismail N, Siddiqui A, Simonyan V, Oliveira F, Coutinho-Abreu IV, DeSouza-Vieira T, Meneses C, Oristian J, Serafim TD, Musa A, Nakamura R, Saljoughian N, Volpedo G, Satoskar M, Satoskar S, Dagur PK, McCoy JP, Kamhawi S, Valenzuela JG, Hamano S, Satoskar AR, Matlashewski G, Nakhasi HL. Zhang WW, et al. Nat Commun. 2020 Jul 10;11(1):3461. doi: 10.1038/s41467-020-17154-z. Nat Commun. 2020. PMID: 32651371 Free PMC article.
SALO, a novel classical pathway complement inhibitor from saliva of the sand fly Lutzomyia longipalpis.
Ferreira VP, Fazito Vale V, Pangburn MK, Abdeladhim M, Mendes-Sousa AF, Coutinho-Abreu IV, Rasouli M, Brandt EA, Meneses C, Lima KF, Nascimento Araújo R, Pereira MH, Kotsyfakis M, Oliveira F, Kamhawi S, Ribeiro JM, Gontijo NF, Collin N, Valenzuela JG. Ferreira VP, et al. Sci Rep. 2016 Jan 13;6:19300. doi: 10.1038/srep19300. Sci Rep. 2016. PMID: 26758086 Free PMC article.
Gut Microbes Egested during Bites of Infected Sand Flies Augment Severity of Leishmaniasis via Inflammasome-Derived IL-1β.
Dey R, Joshi AB, Oliveira F, Pereira L, Guimarães-Costa AB, Serafim TD, de Castro W, Coutinho-Abreu IV, Bhattacharya P, Townsend S, Aslan H, Perkins A, Karmakar S, Ismail N, Karetnick M, Meneses C, Duncan R, Nakhasi HL, Valenzuela JG, Kamhawi S. Dey R, et al. Cell Host Microbe. 2018 Jan 10;23(1):134-143.e6. doi: 10.1016/j.chom.2017.12.002. Epub 2017 Dec 28. Cell Host Microbe. 2018. PMID: 29290574 Free PMC article.
Safety and immunogenicity of a mosquito saliva peptide-based vaccine: a randomised, placebo-controlled, double-blind, phase 1 trial.
Manning JE, Oliveira F, Coutinho-Abreu IV, Herbert S, Meneses C, Kamhawi S, Baus HA, Han A, Czajkowski L, Rosas LA, Cervantes-Medina A, Athota R, Reed S, Mateja A, Hunsberger S, James E, Pleguezuelos O, Stoloff G, Valenzuela JG, Memoli MJ. Manning JE, et al. Lancet. 2020 Jun 27;395(10242):1998-2007. doi: 10.1016/S0140-6736(20)31048-5. Epub 2020 Jun 11. Lancet. 2020. PMID: 32534628 Free PMC article. Clinical Trial.
43 results