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Page 1
Synthesis and Biological Evaluation of Shishijimicin A-Type Linker-Drugs and Antibody-Drug Conjugates.
Nicolaou KC, Li R, Chen Q, Lu Z, Pitsinos EN, Schammel A, Lin B, Gu C, Sarvaiya H, Tchelepi R, Valdiosera A, Clubb J, Barbour N, Sisodiya V, Sandoval J, Lee C, Aujay M, Gavrilyuk J. Nicolaou KC, et al. Among authors: schammel a. J Am Chem Soc. 2020 Jul 22;142(29):12890-12899. doi: 10.1021/jacs.0c06554. Epub 2020 Jul 14. J Am Chem Soc. 2020. PMID: 32662641
Uncialamycin-based antibody-drug conjugates: Unique enediyne ADCs exhibiting bystander killing effect.
Nicolaou KC, Rigol S, Pitsinos EN, Das D, Lu Y, Rout S, Schammel AW, Holte D, Lin B, Gu C, Sarvaiya H, Trinidad J, Barbour N, Valdiosera AM, Sandoval J, Lee C, Aujay M, Fernando H, Dhar A, Karsunky H, Taylor N, Pysz M, Gavrilyuk J. Nicolaou KC, et al. Among authors: schammel aw. Proc Natl Acad Sci U S A. 2021 Jun 22;118(25):e2107042118. doi: 10.1073/pnas.2107042118. Proc Natl Acad Sci U S A. 2021. PMID: 34155147 Free PMC article.
ABBV-011, A Novel, Calicheamicin-Based Antibody-Drug Conjugate, Targets SEZ6 to Eradicate Small Cell Lung Cancer Tumors.
Wiedemeyer WR, Gavrilyuk J, Schammel A, Zhao X, Sarvaiya H, Pysz M, Gu C, You M, Isse K, Sullivan T, French D, Lee C, Dang AT, Zhang Z, Aujay M, Bankovich AJ, Vitorino P. Wiedemeyer WR, et al. Among authors: schammel a. Mol Cancer Ther. 2022 Jun 1;21(6):986-998. doi: 10.1158/1535-7163.MCT-21-0851. Mol Cancer Ther. 2022. PMID: 35642431 Free PMC article.
Total syntheses and initial evaluation of [Ψ[C(═S)NH]Tpg⁴]vancomycin, [Ψ[C(═NH)NH]Tpg⁴]vancomycin, [Ψ[CH₂NH]Tpg⁴]vancomycin, and their (4-chlorobiphenyl)methyl derivatives: synergistic binding pocket and peripheral modifications for the glycopeptide antibiotics.
Okano A, Nakayama A, Wu K, Lindsey EA, Schammel AW, Feng Y, Collins KC, Boger DL. Okano A, et al. Among authors: schammel aw. J Am Chem Soc. 2015 Mar 18;137(10):3693-704. doi: 10.1021/jacs.5b01008. Epub 2015 Mar 9. J Am Chem Soc. 2015. PMID: 25750995 Free PMC article.
14 results