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Page 1
Design, Synthesis and Biological Evaluation of Novel Triazole N-acylhydrazone Hybrids for Alzheimer's Disease.
de Freitas Silva M, Tardelli Lima E, Pruccoli L, Castro NG, Guimarães MJR, M R da Silva F, Fonseca Nadur N, de Azevedo LL, Kümmerle AE, Guedes IA, Dardenne LE, Gontijo VS, Tarozzi A, Viegas C. de Freitas Silva M, et al. Among authors: dardenne le. Molecules. 2020 Jul 10;25(14):3165. doi: 10.3390/molecules25143165. Molecules. 2020. PMID: 32664425 Free PMC article.
A unique SaeS allele overrides cell-density dependent expression of saeR and lukSF-PV in the ST30-SCCmecIV lineage of CA-MRSA.
Ramundo MS, Beltrame CO, Botelho AM, Coelho LR, Silva-Carvalho MC, Ferreira-Carvalho BT, Nicolás MF, Guedes IA, Dardenne LE, O'Gara J, Figueiredo AM. Ramundo MS, et al. Among authors: dardenne le. Int J Med Microbiol. 2016 Sep;306(6):367-80. doi: 10.1016/j.ijmm.2016.05.001. Epub 2016 May 11. Int J Med Microbiol. 2016. PMID: 27265234
Novel series of tacrine-tianeptine hybrids: Synthesis, cholinesterase inhibitory activity, S100B secretion and a molecular modeling approach.
Ceschi MA, da Costa JS, Lopes JPB, Câmara VS, Campo LF, Borges ACA, Gonçalves CAS, de Souza DF, Konrath EL, Karl ALM, Guedes IA, Dardenne LE. Ceschi MA, et al. Among authors: dardenne le. Eur J Med Chem. 2016 Oct 4;121:758-772. doi: 10.1016/j.ejmech.2016.06.025. Epub 2016 Jun 23. Eur J Med Chem. 2016. PMID: 27392529
Design, synthesis and evaluation of novel feruloyl-donepezil hybrids as potential multitarget drugs for the treatment of Alzheimer's disease.
Dias KS, de Paula CT, Dos Santos T, Souza IN, Boni MS, Guimarães MJ, da Silva FM, Castro NG, Neves GA, Veloso CC, Coelho MM, de Melo IS, Giusti FC, Giusti-Paiva A, da Silva ML, Dardenne LE, Guedes IA, Pruccoli L, Morroni F, Tarozzi A, Viegas C Jr. Dias KS, et al. Among authors: dardenne le. Eur J Med Chem. 2017 Apr 21;130:440-457. doi: 10.1016/j.ejmech.2017.02.043. Epub 2017 Feb 21. Eur J Med Chem. 2017. PMID: 28282613
Receptor-ligand molecular docking.
Guedes IA, de Magalhães CS, Dardenne LE. Guedes IA, et al. Among authors: dardenne le. Biophys Rev. 2014 Mar;6(1):75-87. doi: 10.1007/s12551-013-0130-2. Epub 2013 Dec 21. Biophys Rev. 2014. PMID: 28509958 Free PMC article. Review.
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.
Dias Viegas FP, de Freitas Silva M, Divino da Rocha M, Castelli MR, Riquiel MM, Machado RP, Vaz SM, Simões de Lima LM, Mancini KC, Marques de Oliveira PC, Morais ÉP, Gontijo VS, da Silva FMR, D'Alincourt da Fonseca Peçanha D, Castro NG, Neves GA, Giusti-Paiva A, Vilela FC, Orlandi L, Camps I, Veloso MP, Leomil Coelho LF, Ionta M, Ferreira-Silva GÁ, Pereira RM, Dardenne LE, Guedes IA, de Oliveira Carneiro Junior W, Quaglio Bellozi PM, Pinheiro de Oliveira AC, Ferreira FF, Pruccoli L, Tarozzi A, Viegas C Jr. Dias Viegas FP, et al. Among authors: dardenne le. Eur J Med Chem. 2018 Mar 10;147:48-65. doi: 10.1016/j.ejmech.2018.01.066. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29421570
33 results