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Meta-Analysis of the Alzheimer's Disease Human Brain Transcriptome and Functional Dissection in Mouse Models.
Wan YW, Al-Ouran R, Mangleburg CG, Perumal TM, Lee TV, Allison K, Swarup V, Funk CC, Gaiteri C, Allen M, Wang M, Neuner SM, Kaczorowski CC, Philip VM, Howell GR, Martini-Stoica H, Zheng H, Mei H, Zhong X, Kim JW, Dawson VL, Dawson TM, Pao PC, Tsai LH, Haure-Mirande JV, Ehrlich ME, Chakrabarty P, Levites Y, Wang X, Dammer EB, Srivastava G, Mukherjee S, Sieberts SK, Omberg L, Dang KD, Eddy JA, Snyder P, Chae Y, Amberkar S, Wei W, Hide W, Preuss C, Ergun A, Ebert PJ, Airey DC, Mostafavi S, Yu L, Klein HU; Accelerating Medicines Partnership-Alzheimer’s Disease Consortium; Carter GW, Collier DA, Golde TE, Levey AI, Bennett DA, Estrada K, Townsend TM, Zhang B, Schadt E, De Jager PL, Price ND, Ertekin-Taner N, Liu Z, Shulman JM, Mangravite LM, Logsdon BA. Wan YW, et al. Among authors: schadt e. Cell Rep. 2020 Jul 14;32(2):107908. doi: 10.1016/j.celrep.2020.107908. Cell Rep. 2020. PMID: 32668255 Free PMC article.
Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.
Readhead B, Haure-Mirande JV, Zhang B, Haroutunian V, Gandy S, Schadt EE, Dudley JT, Ehrlich ME. Readhead B, et al. Among authors: schadt ee. Mol Psychiatry. 2016 Aug;21(8):1099-111. doi: 10.1038/mp.2015.167. Epub 2015 Nov 10. Mol Psychiatry. 2016. PMID: 26552589 Free PMC article.
Large eQTL meta-analysis reveals differing patterns between cerebral cortical and cerebellar brain regions.
Sieberts SK, Perumal TM, Carrasquillo MM, Allen M, Reddy JS, Hoffman GE, Dang KK, Calley J, Ebert PJ, Eddy J, Wang X, Greenwood AK, Mostafavi S; CommonMind Consortium (CMC); The AMP-AD Consortium; Omberg L, Peters MA, Logsdon BA, De Jager PL, Ertekin-Taner N, Mangravite LM. Sieberts SK, et al. Sci Data. 2020 Oct 12;7(1):340. doi: 10.1038/s41597-020-00642-8. Sci Data. 2020. PMID: 33046718 Free PMC article.
Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease.
Wang M, Roussos P, McKenzie A, Zhou X, Kajiwara Y, Brennand KJ, De Luca GC, Crary JF, Casaccia P, Buxbaum JD, Ehrlich M, Gandy S, Goate A, Katsel P, Schadt E, Haroutunian V, Zhang B. Wang M, et al. Among authors: schadt e. Genome Med. 2016 Nov 1;8(1):104. doi: 10.1186/s13073-016-0355-3. Genome Med. 2016. PMID: 27799057 Free PMC article.
GJA1 (connexin43) is a key regulator of Alzheimer's disease pathogenesis.
Kajiwara Y, Wang E, Wang M, Sin WC, Brennand KJ, Schadt E, Naus CC, Buxbaum J, Zhang B. Kajiwara Y, et al. Among authors: schadt e. Acta Neuropathol Commun. 2018 Dec 21;6(1):144. doi: 10.1186/s40478-018-0642-x. Acta Neuropathol Commun. 2018. PMID: 30577786 Free PMC article.
Systems modeling of white matter microstructural abnormalities in Alzheimer's disease.
Horgusluoglu-Moloch E, Xiao G, Wang M, Wang Q, Zhou X, Nho K, Saykin AJ, Schadt E, Zhang B; Alzheimer's Disease Neuroimaging Initiative (ADNI). Horgusluoglu-Moloch E, et al. Among authors: schadt e. Neuroimage Clin. 2020;26:102203. doi: 10.1016/j.nicl.2020.102203. Epub 2020 Feb 4. Neuroimage Clin. 2020. PMID: 32062565 Free PMC article.
Moving toward a system genetics view of disease.
Sieberts SK, Schadt EE. Sieberts SK, et al. Among authors: schadt ee. Mamm Genome. 2007 Jul;18(6-7):389-401. doi: 10.1007/s00335-007-9040-6. Epub 2007 Jul 26. Mamm Genome. 2007. PMID: 17653589 Free PMC article. Review.
542 results