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Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells.
Janssen E, Morbach H, Ullas S, Bannock JM, Massad C, Menard L, Barlan I, Lefranc G, Su H, Dasouki M, Al-Herz W, Keles S, Chatila T, Geha RS, Meffre E. Janssen E, et al. J Allergy Clin Immunol. 2014 Dec;134(6):1365-1374. doi: 10.1016/j.jaci.2014.07.042. Epub 2014 Sep 11. J Allergy Clin Immunol. 2014. PMID: 25218284 Free PMC article.
PTPN22 inhibition resets defective human central B cell tolerance.
Schickel JN, Kuhny M, Baldo A, Bannock JM, Massad C, Wang H, Katz N, Oe T, Menard L, Soulas-Sprauel P, Strowig T, Flavell R, Meffre E. Schickel JN, et al. Sci Immunol. 2016;1(1):aaf7153. doi: 10.1126/sciimmunol.aaf7153. Epub 2016 Jul 22. Sci Immunol. 2016. PMID: 27917411 Free PMC article.
Positive and negative selection shape the human naive B cell repertoire.
Chen JW, Schickel JN, Tsakiris N, Sng J, Arbogast F, Bouis D, Parisi D, Gera R, Boeckers JM, Delmotte FR, Veselits M, Schuetz C, Jacobsen EM, Posovszky C, Schulz AS, Schwarz K, Clark MR, Menard L, Meffre E. Chen JW, et al. J Clin Invest. 2022 Jan 18;132(2):e150985. doi: 10.1172/JCI150985. J Clin Invest. 2022. PMID: 34813502 Free PMC article.
Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens.
Young RM, Wu T, Schmitz R, Dawood M, Xiao W, Phelan JD, Xu W, Menard L, Meffre E, Chan WC, Jaffe ES, Gascoyne RD, Campo E, Rosenwald A, Ott G, Delabie J, Rimsza LM, Staudt LM. Young RM, et al. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):13447-54. doi: 10.1073/pnas.1514944112. Epub 2015 Oct 19. Proc Natl Acad Sci U S A. 2015. PMID: 26483459 Free PMC article.
23 results