Blundell TL - Search Results

1

Correction to Fragment-Based Design of Mycobacterium tuberculosis InhA Inhibitors.

Sabbah M, Mendes V, Vistal RG, Dias DMG, Záhorszká M, Mikušová K, Korduláková J, Coyne AG, Blundell TL, Abell C. Sabbah M, et al. Among authors: blundell tl. J Med Chem. 2020 Aug 13;63(15):8650. doi: 10.1021/acs.jmedchem.0c01187. Epub 2020 Jul 22. J Med Chem. 2020. PMID: 32697583 Free PMC article. No abstract available.

2

High-throughput crystallography for lead discovery in drug design.

Blundell TL, Jhoti H, Abell C. Blundell TL, et al. Nat Rev Drug Discov. 2002 Jan;1(1):45-54. doi: 10.1038/nrd706. Nat Rev Drug Discov. 2002. PMID: 12119609 Review.

3

Probing hot spots at protein-ligand binding sites: a fragment-based approach using biophysical methods.

Ciulli A, Williams G, Smith AG, Blundell TL, Abell C. Ciulli A, et al. Among authors: blundell tl. J Med Chem. 2006 Aug 10;49(16):4992-5000. doi: 10.1021/jm060490r. J Med Chem. 2006. PMID: 16884311

4

Crystal structure of Escherichia coli ketopantoate reductase in a ternary complex with NADP+ and pantoate bound: substrate recognition, conformational change, and cooperativity.

Ciulli A, Chirgadze DY, Smith AG, Blundell TL, Abell C. Ciulli A, et al. Among authors: blundell tl. J Biol Chem. 2007 Mar 16;282(11):8487-97. doi: 10.1074/jbc.M611171200. Epub 2007 Jan 16. J Biol Chem. 2007. PMID: 17229734 Free article.

5

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.

Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C. Hung AW, et al. Among authors: blundell tl. Angew Chem Int Ed Engl. 2009;48(45):8452-6. doi: 10.1002/anie.200903821. Angew Chem Int Ed Engl. 2009. PMID: 19780086 No abstract available.

6

Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase.

Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C. Sledz P, et al. Among authors: blundell tl. J Am Chem Soc. 2010 Apr 7;132(13):4544-5. doi: 10.1021/ja100595u. J Am Chem Soc. 2010. PMID: 20232910 Free PMC article.

7

Discovery of Schaeffer's acid analogues as lead structures of mycobacterium tuberculosis type II dehydroquinase using a rational drug design approach.

Schmidt MF, Korb O, Howard NI, Dias MV, Blundell TL, Abell C. Schmidt MF, et al. Among authors: blundell tl. ChemMedChem. 2013 Jan;8(1):54-8. doi: 10.1002/cmdc.201200508. Epub 2012 Nov 21. ChemMedChem. 2013. PMID: 23169689

8

Integrated biophysical approach to fragment screening and validation for fragment-based lead discovery.

Silvestre HL, Blundell TL, Abell C, Ciulli A. Silvestre HL, et al. Among authors: blundell tl. Proc Natl Acad Sci U S A. 2013 Aug 6;110(32):12984-9. doi: 10.1073/pnas.1304045110. Epub 2013 Jul 19. Proc Natl Acad Sci U S A. 2013. PMID: 23872845 Free PMC article.

9

Design and structural analysis of aromatic inhibitors of type II dehydroquinase from Mycobacterium tuberculosis.

Howard NI, Dias MV, Peyrot F, Chen L, Schmidt MF, Blundell TL, Abell C. Howard NI, et al. Among authors: blundell tl. ChemMedChem. 2015 Jan;10(1):116-33. doi: 10.1002/cmdc.201402298. Epub 2014 Sep 18. ChemMedChem. 2015. PMID: 25234229

10

Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases.

Scott DE, Coyne AG, Venkitaraman A, Blundell TL, Abell C, Hyvönen M. Scott DE, et al. Among authors: blundell tl. ChemMedChem. 2015 Feb;10(2):296-303. doi: 10.1002/cmdc.201402428. Epub 2014 Dec 2. ChemMedChem. 2015. PMID: 25470112 Free PMC article.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My Custom Filters

Publication date

Text availability

Article attribute

Article type

Article Language

Species

Sex

Age

Other

617 results

Search Page

Filters