Scheffzek K - Search Results

1

Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR.

Yan W, Markegard E, Dharmaiah S, Urisman A, Drew M, Esposito D, Scheffzek K, Nissley DV, McCormick F, Simanshu DK. Yan W, et al. Among authors: scheffzek k. Cell Rep. 2020 Jul 21;32(3):107909. doi: 10.1016/j.celrep.2020.107909. Cell Rep. 2020. PMID: 32697994 Free PMC article.

2

The neurofibromin recruitment factor Spred1 binds to the GAP related domain without affecting Ras inactivation.

Dunzendorfer-Matt T, Mercado EL, Maly K, McCormick F, Scheffzek K. Dunzendorfer-Matt T, et al. Among authors: scheffzek k. Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):7497-502. doi: 10.1073/pnas.1607298113. Epub 2016 Jun 16. Proc Natl Acad Sci U S A. 2016. PMID: 27313208 Free PMC article.

3

Restoring functional neurofibromin by protein transduction.

Mellert K, Lechner S, Lüdeke M, Lamla M, Möller P, Kemkemer R, Scheffzek K, Kaufmann D. Mellert K, et al. Among authors: scheffzek k. Sci Rep. 2018 Apr 18;8(1):6171. doi: 10.1038/s41598-018-24310-5. Sci Rep. 2018. PMID: 29670214 Free PMC article.

4

Structural basis of activation of the tumor suppressor protein neurofibromin.

Chaker-Margot M, Werten S, Dunzendorfer-Matt T, Lechner S, Ruepp A, Scheffzek K, Maier T. Chaker-Margot M, et al. Among authors: scheffzek k. Mol Cell. 2022 Apr 7;82(7):1288-1296.e5. doi: 10.1016/j.molcel.2022.03.011. Epub 2022 Mar 29. Mol Cell. 2022. PMID: 35353986 Free article.

5

NMR resonance assignments of the EVH1 domain of neurofibromin's recruitment factor Spred1.

Führer S, Ahammer L, Ausserbichler A, Scheffzek K, Dunzendorfer-Matt T, Tollinger M. Führer S, et al. Among authors: scheffzek k. Biomol NMR Assign. 2017 Oct;11(2):305-308. doi: 10.1007/s12104-017-9768-1. Epub 2017 Aug 22. Biomol NMR Assign. 2017. PMID: 28831766 Free PMC article.

6

LAMTOR/Ragulator is a negative regulator of Arl8b- and BORC-dependent late endosomal positioning.

Filipek PA, de Araujo MEG, Vogel GF, De Smet CH, Eberharter D, Rebsamen M, Rudashevskaya EL, Kremser L, Yordanov T, Tschaikner P, Fürnrohr BG, Lechner S, Dunzendorfer-Matt T, Scheffzek K, Bennett KL, Superti-Furga G, Lindner HH, Stasyk T, Huber LA. Filipek PA, et al. Among authors: scheffzek k. J Cell Biol. 2017 Dec 4;216(12):4199-4215. doi: 10.1083/jcb.201703061. Epub 2017 Oct 9. J Cell Biol. 2017. PMID: 28993467 Free PMC article.

7

Ras-Specific GTPase-Activating Proteins-Structures, Mechanisms, and Interactions.

Scheffzek K, Shivalingaiah G. Scheffzek K, et al. Cold Spring Harb Perspect Med. 2019 Mar 1;9(3):a031500. doi: 10.1101/cshperspect.a031500. Cold Spring Harb Perspect Med. 2019. PMID: 30104198 Free PMC article. Review.

8

Structural basis for the autoinhibition of c-Abl tyrosine kinase.

Nagar B, Hantschel O, Young MA, Scheffzek K, Veach D, Bornmann W, Clarkson B, Superti-Furga G, Kuriyan J. Nagar B, et al. Among authors: scheffzek k. Cell. 2003 Mar 21;112(6):859-71. doi: 10.1016/s0092-8674(03)00194-6. Cell. 2003. PMID: 12654251 Free article.

9

Structural and biochemical consequences of NF1 associated nontruncating mutations in the Sec14-PH module of neurofibromin.

Welti S, Kühn S, D'Angelo I, Brügger B, Kaufmann D, Scheffzek K. Welti S, et al. Among authors: scheffzek k. Hum Mutat. 2011 Feb;32(2):191-7. doi: 10.1002/humu.21405. Epub 2011 Jan 18. Hum Mutat. 2011. PMID: 21089070

10

Selective disactivation of neurofibromin GAP activity in neurofibromatosis type 1.

Klose A, Ahmadian MR, Schuelke M, Scheffzek K, Hoffmeyer S, Gewies A, Schmitz F, Kaufmann D, Peters H, Wittinghofer A, Nürnberg P. Klose A, et al. Among authors: scheffzek k. Hum Mol Genet. 1998 Aug;7(8):1261-8. doi: 10.1093/hmg/7.8.1261. Hum Mol Genet. 1998. PMID: 9668168

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